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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 69.2 | $ 127.4
Capitalized research and development expenses | 53.6 | 57.1
Tax credits | 101.1 | 78.6
Share-based compensation | 13.0 | 10.9
Fixed and intangible assets | 16.9 | 14.0
Accrued liabilities and reserves | 110.3 | 62.0
Convertible debt | 0.0 | 1.7
Total gross deferred tax assets | 364.1 | 351.7
Less: valuation allowance | (55.5) | (332.2)
Total net deferred tax assets | 308.6 | 19.5
Deferred tax liabilities: |  |
Fixed assets and acquired intangibles assets | (36.3) | (19.6)
Convertible debt discount | (55.9) | 0.0
Total deferred tax liabilities | (92.2) | (19.6)
Net deferred tax assets (liabilities) | $ 216.4 |
Net deferred tax assets (liabilities) |  | $ (0.1)

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