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Consolidated Statements of Operations - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Statement [Abstract]      
Revenue $ 1,926.7 $ 1,476.0 $ 1,031.6
Cost of sales 646.6 544.5 367.7
Gross profit 1,280.1 931.5 663.9
Operating expenses      
Research and development 359.9 273.5 199.7
Collaborative research and development fee 0.0 0.0 217.7
Selling, general and administrative 620.7 515.7 432.8
Total operating expenses 980.6 789.2 850.2
Operating income (loss) 299.5 142.3 (186.3)
Interest expense (84.7) (60.3) (22.7)
Loss on extinguishment of debt (5.9) 0.0 0.0
Income (loss) from equity investments 0.0 (4.2) 80.1
Interest and other income, net 16.1 26.4 2.4
Income (loss) before income taxes 225.0 104.2 (126.5)
Income tax expense (benefit) (268.6) 3.1 0.6
Net income (loss) $ 493.6 $ 101.1 $ (127.1)
Basic net income (loss) per share (USD per share) $ 5.23 $ 1.11 $ (1.44)
Shares used to compute basic net income (loss) per share (shares) 94.4 91.1 88.2
Diluted net income (loss) per share (USD per share) $ 5.06 $ 1.10 $ (1.44)
Shares used to compute diluted net income (loss) per share (shares) 97.5 92.3 88.2