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Income Taxes - Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Effective Income Tax Rate Reconciliation, Amount [Abstract]
U.S. federal statutory tax rate	$ 47.3	$ 21.9	$ (26.6)
State income tax, net of federal benefit	3.2	(2.3)	(5.5)
Permanent items	13.1	1.0	1.3
Research and development credits	(24.4)	(10.8)	(11.7)
Foreign rate differential	(0.1)	5.6	3.7
Stock and officers compensation	(28.7)	(14.7)	(5.1)
Change in statutory tax rates	(4.1)	0.0	0.0
Impact of adoption of ASU 2016-16	0.0	0.0	(13.3)
Impact of Tax Cuts and Jobs Act of 2017	0.0	0.0	(0.4)
Other	0.1	(1.0)	1.3
Change in valuation allowance	(275.0)	3.4	56.9
Income taxes at effective rates	$ (268.6)	$ 3.1	$ 0.6

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