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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Millions
Total
Cumulative Effect, Period of Adoption, Adjustment
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjustment
Treasury Stock
Accounting Standards Update [Extensible List] us-gaap:AccountingStandardsUpdate201602Member              
Balance at beginning of period (shares) at Dec. 31, 2017     87,000,000.0          
Balance at beginning of period at Dec. 31, 2017 $ 419.4   $ 0.1 $ 1,093.7 $ (2.6) $ (671.8)   $ 0.0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (shares)     1,800,000          
Issuance of common stock under equity incentive plans 1.9     1.9        
Issuance of common stock for Employee Stock Purchase Plan (shares)     200,000          
Issuance of common stock for Employee Stock Purchase Plan 8.9     8.9        
Issuance of common stock for collaborative research and development fee (shares)     1,800,000          
Issuance of common stock for collaborative research and development fee 217.7     217.7        
Convertible note hedge (218.9)     (218.9)        
Equity component of convertible note issuance, net of issuance costs $ 171.6     171.6        
Purchases of treasury stock (shares) (800,000)   (800,000)          
Purchases of treasury stock $ (100.0)             (100.0)
Sale of warrants 183.8     183.8        
Share-based compensation expense 101.9     101.9        
Net income (loss) (127.1)         (127.1)    
Other comprehensive income, net of tax 4.1       4.1      
Balance at end of period (shares) at Dec. 31, 2018     90,000,000.0          
Balance at end of period at Dec. 31, 2018 663.3 $ 2.1 $ 0.1 1,560.6 1.5 (798.9) $ 2.1 (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (shares)     1,400,000          
Issuance of common stock under equity incentive plans 0.3     0.3        
Issuance of common stock for Employee Stock Purchase Plan (shares)     200,000          
Issuance of common stock for Employee Stock Purchase Plan 11.6     11.6        
Tax benefit from Notes $ 0.7     0.7        
Purchases of treasury stock (shares) 0              
Share-based compensation expense $ 102.7     102.7        
Net income (loss) 101.1         101.1    
Other comprehensive income, net of tax 0.8       0.8      
Balance at end of period (shares) at Dec. 31, 2019     91,600,000          
Balance at end of period at Dec. 31, 2019 882.6   $ 0.1 1,675.9 2.3 (695.7)   (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (shares)     1,100,000          
Issuance of common stock under equity incentive plans 0.3     0.3        
Issuance of common stock for Employee Stock Purchase Plan 15.0     15.0        
Equity component of convertible note issuance, net of issuance costs 289.4     289.4        
Tax benefit from Notes (62.5)     (62.5)        
Repurchase and conversions of 2022 notes (in shares)     3,400,000          
Repurchase and conversions of 2022 Notes $ 87.8     87.8        
Purchases of treasury stock (shares) 0              
Share-based compensation expense $ 119.4     119.4        
Net income (loss) 493.6         493.6    
Other comprehensive income, net of tax 0.9       0.9      
Balance at end of period (shares) at Dec. 31, 2020     96,100,000          
Balance at end of period at Dec. 31, 2020 $ 1,826.5   $ 0.1 $ 2,125.3 $ 3.2 $ (202.1)   $ (100.0)