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Employee Benefit Plans and Stockholders' Equity - Share-based Compensation Expenses (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Share-based compensation expense included in operating expenses $ 119.4 $ 102.7 $ 101.9
Cost of sales      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Share-based compensation expense included in operating expenses 14.6 9.0 9.2
Research and development      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Share-based compensation expense included in operating expenses 37.8 33.5 33.0
Selling, general and administrative      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Share-based compensation expense included in operating expenses $ 67.0 $ 60.2 $ 59.7