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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Operating activities      
Net income (loss) $ 493.6 $ 101.1 $ (127.1)
Adjustments to reconcile net income (loss) to cash provided by operating activities:      
Depreciation and amortization 67.1 48.7 29.1
Share-based compensation 119.4 102.7 101.9
Loss on extinguishment of debt 5.9 0.0 0.0
Non-cash interest expense 74.0 49.6 17.9
Non-cash collaborative research and development fee through issuance of common stock 0.0 0.0 217.7
Unrealized gain on equity investment 0.0 0.0 (36.0)
Realized (gain) loss on equity investment 0.0 4.2 (44.1)
Deferred income taxes (including benefit from valuation allowance release) (277.3) 0.2 (2.2)
Other non-cash income and expenses 13.7 1.9 6.9
Changes in operating assets and liabilities:      
Accounts receivable, net (142.3) (60.0) (93.2)
Inventory (114.5) (49.1) (25.5)
Prepaid and other assets (2.4) (7.2) (3.0)
Operating lease right-of-use assets and liabilities, net (0.8) (2.4) 0.0
Accounts payable and accrued liabilities 194.5 109.0 56.2
Accrued payroll and related expenses 26.1 16.0 23.8
Deferred revenue and other liabilities 18.6 (0.2) 0.8
Net cash provided by operating activities 475.6 314.5 123.2
Investing activities      
Purchase of marketable securities (3,058.2) (2,030.4) (452.5)
Proceeds from sale and maturity of marketable securities 2,250.5 1,196.4 392.1
Purchases of property and equipment (199.0) (180.0) (67.1)
Acquisitions, net of cash acquired 0.0 0.0 (11.3)
Other investing activities (11.3) (1.2) (1.0)
Net cash used in investing activities (1,018.0) (1,015.2) (139.8)
Financing activities      
Net proceeds from issuance of common stock 15.3 11.9 10.8
Purchases of treasury stock 0.0 0.0 (100.0)
Proceeds from issuance of convertible notes, net of issuance costs 1,188.8 0.0 836.6
Repurchase of convertible notes (282.6) 0.0 0.0
Proceeds from sale of warrants 0.0 0.0 183.8
Purchase of convertible note hedge 0.0 0.0 (218.9)
Other financing activities (9.4) (1.2) (1.9)
Net cash provided by financing activities 912.1 10.7 710.4
Effect of exchange rate changes on cash, cash equivalents and restricted cash 2.1 (0.7) 1.8
Increase (decrease) in cash, cash equivalents and restricted cash 371.8 (690.7) 695.6
Cash, cash equivalents and restricted cash, beginning of period 446.4 1,137.1 441.5
Cash, cash equivalents and restricted cash, end of period 818.2 446.4 1,137.1
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Total cash, cash equivalents and restricted cash 818.2 1,137.1 1,137.1
Supplemental disclosure of non-cash investing and financing transactions:      
Common stock issued for repurchase and conversions of senior convertible notes 1,350.9 0.0 0.0
Acquisition of property and equipment included in accounts payable and accrued liabilities 35.3 14.2 10.8
Supplemental cash flow information:      
Cash paid during the year for interest 10.6 10.4 3.6
Cash paid during the year for income taxes $ 3.6 $ 4.8 $ 2.3