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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Millions | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Deferred tax assets: |  |  |  |
Net operating loss carryforwards | $ 53.0 | $ 53.0 | $ 69.2 |
Capitalized research and development expenses | 49.3 | 49.3 | 53.6 |
Tax credits | 105.5 | 105.5 | 101.1 |
Share-based compensation | 13.3 | 13.3 | 13.0 |
Fixed and intangible assets | 26.4 | 26.4 | 16.9 |
Accrued liabilities and reserves | 105.5 | 105.5 | 110.3 |
Collaborative agreement milestone accrual | 21.9 | 21.9 | 0.0 |
Other | 0.5 | 0.5 | 0.0 |
Total gross deferred tax assets | 375.4 | 375.4 | 364.1 |
Less: valuation allowance | (69.9) | (69.9) | (55.5) |
Total net deferred tax assets | 305.5 | 305.5 | 308.6 |
Deferred tax liabilities: |  |  |  |
Fixed assets and acquired intangibles assets | (42.5) | (42.5) | (36.3) |
Convertible debt discount | (48.1) | (48.1) | (55.9) |
Total deferred tax liabilities | (90.6) | (90.6) | (92.2) |
Net deferred tax assets (liabilities) | 214.9 | 214.9 | 216.4 |
Collaborative research and development fee | $ 87.1 | $ 87.1 | $ 0.0 | $ 0.0

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