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Balance Sheet Details - Short-term Marketable Securities, Available-for-Sale (Details) - USD ($) $ in Millions | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Condensed Financial Statements, Captions [Line Items] |  |
Amortized Cost | $ 1,680.6 | $ 1,890.0
Gross Unrealized Gains | 0.0 | 0.2
Gross Unrealized Losses | (2.0) | (0.1)
Estimated Market Value | 1,678.6 | 1,890.1
U.S. government agencies |  |
Condensed Financial Statements, Captions [Line Items] |  |
Amortized Cost | 1,212.1 | 1,570.4
Gross Unrealized Gains | 0.0 | 0.1
Gross Unrealized Losses | (1.5) | (0.1)
Estimated Market Value | 1,210.6 | 1,570.4
Commercial paper |  |
Condensed Financial Statements, Captions [Line Items] |  |
Amortized Cost | 189.8 | 258.7
Gross Unrealized Gains | 0.0 | 0.1
Gross Unrealized Losses | (0.1) | 0.0
Estimated Market Value | 189.7 | 258.8
Corporate debt |  |
Condensed Financial Statements, Captions [Line Items] |  |
Amortized Cost | 224.6 | 60.9
Gross Unrealized Gains | 0.0 | 0.0
Gross Unrealized Losses | (0.3) | 0.0
Estimated Market Value | 224.3 | $ 60.9
Supranationals |  |
Condensed Financial Statements, Captions [Line Items] |  |
Amortized Cost | 54.1 |
Gross Unrealized Gains | 0.0 |
Gross Unrealized Losses | (0.1) |
Estimated Market Value | $ 54.0 |

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