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Consolidated Statements of Operations - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Statement [Abstract]      
Revenue $ 2,448.5 $ 1,926.7 $ 1,476.0
Cost of sales 768.0 646.6 544.5
Gross profit 1,680.5 1,280.1 931.5
Operating expenses:      
Research and development 517.1 359.9 273.5
Collaborative research and development fee 87.1 0.0 0.0
Selling, general and administrative 810.5 620.7 515.7
Total operating expenses 1,414.7 980.6 789.2
Operating income 265.8 299.5 142.3
Interest expense (100.3) (84.7) (60.3)
Loss on extinguishment of debt (1.5) (5.9) 0.0
Income (loss) from equity investments 11.6 0.0 (4.2)
Interest and other income (expense), net (1.7) 16.1 26.4
Income before income taxes 173.9 225.0 104.2
Income tax expense (benefit) 19.2 (268.6) 3.1
Net income $ 154.7 $ 493.6 $ 101.1
Basic net income per share (USD per share) $ 1.60 $ 5.23 $ 1.11
Shares used to compute basic net income per share (shares) 96.7 94.4 91.1
Diluted net income per share (USD per share) $ 1.55 $ 5.06 $ 1.10
Shares used to compute diluted net income per share (shares) 100.1 97.5 92.3