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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Millions
 3 Months Ended 12 Months Ended
Dec. 31, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Deferred tax assets:        
Net operating loss carryforwards $ 53.0 $ 53.0 $ 69.2  
Capitalized research and development expenses 49.3 49.3 53.6  
Tax credits 105.5 105.5 101.1  
Share-based compensation 13.3 13.3 13.0  
Fixed and intangible assets 26.4 26.4 16.9  
Accrued liabilities and reserves 105.5 105.5 110.3  
Collaborative agreement milestone accrual 21.9 21.9 0.0  
Other 0.5 0.5 0.0  
Total gross deferred tax assets 375.4 375.4 364.1  
Less: valuation allowance (69.9) (69.9) (55.5)  
Total net deferred tax assets 305.5 305.5 308.6  
Deferred tax liabilities:        
Fixed assets and acquired intangibles assets (42.5) (42.5) (36.3)  
Convertible debt discount (48.1) (48.1) (55.9)  
Total deferred tax liabilities (90.6) (90.6) (92.2)  
Net deferred tax assets (liabilities) 214.9 214.9 216.4  
Collaborative research and development fee $ 87.1 $ 87.1 $ 0.0 $ 0.0