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Income Taxes - Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Effective Income Tax Rate Reconciliation, Amount [Abstract]
U.S. federal statutory tax rate	$ 36.5	$ 47.3	$ 21.9
State income tax, net of federal benefit	5.6	3.2	(2.3)
Permanent items	26.2	13.1	1.0
Research and development credits	(28.9)	(24.4)	(10.8)
Foreign tax credit	(3.7)	0.0	0.0
Foreign rate differential	(0.1)	(0.1)	5.6
Stock and officers compensation	(20.4)	(28.7)	(14.7)
Change in statutory tax rates	(10.0)	(4.1)	0.0
Other	(0.4)	0.1	(1.0)
Change in valuation allowance	14.4	(275.0)	3.4
Income taxes at effective rates	$ 19.2	$ (268.6)	$ 3.1

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