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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Millions, $ in Millions
Total
Cumulative Effect, Period of Adoption, Adjustment
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Accumulated Deficit
Cumulative Effect, Period of Adoption, Adjustment
Treasury Stock
Balance at beginning of period (shares) at Dec. 31, 2018     90.0          
Balance at beginning of period at Dec. 31, 2018 $ 663.3 $ 2.1 $ 0.1 $ 1,560.6 $ 1.5 $ (798.9) $ 2.1 $ (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (in shares)     1.4          
Issuance of common stock under equity incentive plans 0.3     0.3        
Issuance of common stock for Employee Stock Purchase Plan (in shares)     0.2          
Issuance of common stock for Employee Stock Purchase Plan 11.6     11.6        
Tax benefit related to Senior Convertible Notes 0.7     0.7        
Share-based compensation expense 102.7     102.7        
Net income 101.1         101.1    
Other comprehensive income (loss), net of tax 0.8       0.8      
Balance at end of period (shares) at Dec. 31, 2019     91.6          
Balance at end of period at Dec. 31, 2019 882.6   $ 0.1 1,675.9 2.3 (695.7)   (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (in shares)     1.1          
Issuance of common stock under equity incentive plans 0.3     0.3        
Issuance of common stock for Employee Stock Purchase Plan 15.0     15.0        
Equity component of 2025 Notes issuance, net of issuance costs 289.4     289.4        
Tax benefit related to Senior Convertible Notes (62.5)     (62.5)        
Repurchase and conversions of Notes (in shares)     3.4          
Repurchase and conversions of Notes 87.8     87.8        
Share-based compensation expense 119.4     119.4        
Net income 493.6         493.6    
Other comprehensive income (loss), net of tax 0.9       0.9      
Balance at end of period (shares) at Dec. 31, 2020     96.1          
Balance at end of period at Dec. 31, 2020 1,826.5   $ 0.1 2,125.3 3.2 (202.1)   (100.0)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                
Issuance of common stock under equity incentive plans (in shares)     0.7          
Issuance of common stock under equity incentive plans 0.0              
Issuance of common stock for Employee Stock Purchase Plan 20.3     20.3        
Tax benefit related to Senior Convertible Notes (1.1)     (1.1)        
Repurchase and conversions of Notes (in shares)     0.4          
Repurchase and conversions of Notes 53.3     28.7       24.6
Benefit of note hedge upon conversions of 2023 Notes (in shares)     (0.2)          
Benefit of note hedge upon conversions of 2023 Notes 0.0     130.8       (130.8)
Share-based compensation expense 113.4     113.4        
Collaborative research and development fee 87.1     87.1        
Net income 154.7         154.7    
Other comprehensive income (loss), net of tax (2.7)       (2.7)      
Balance at end of period (shares) at Dec. 31, 2021     97.0          
Balance at end of period at Dec. 31, 2021 $ 2,251.5   $ 0.1 $ 2,504.5 $ 0.5 $ (47.4)   $ (206.2)