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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating activities      
Net income $ 154.7 $ 493.6 $ 101.1
Adjustments to reconcile net income to cash provided by operating activities:      
Depreciation and amortization 102.0 67.1 48.7
Share-based compensation 113.4 119.4 102.7
Collaborative research and development fee 87.1 0.0 0.0
Loss on extinguishment of debt 1.5 5.9 0.0
Non-cash interest expense 88.7 74.0 49.6
Realized (gain) loss on equity investment (11.6) 0.0 4.2
Deferred income taxes (including benefit from valuation allowance release) (4.9) (277.3) 0.2
Other non-cash income and expenses 43.6 13.7 1.9
Changes in operating assets and liabilities:      
Accounts receivable, net (75.5) (142.3) (60.0)
Inventory (112.2) (114.5) (49.1)
Prepaid and other assets (21.3) (2.4) (7.2)
Operating lease right-of-use assets and liabilities, net (0.1) (0.8) (2.4)
Accounts payable and accrued liabilities 58.0 194.5 109.0
Accrued payroll and related expenses 10.4 26.1 16.0
Deferred revenue and other liabilities 8.7 18.6 (0.2)
Net cash provided by operating activities 442.5 475.6 314.5
Investing activities      
Purchase of marketable securities (2,473.1) (3,058.2) (2,030.4)
Proceeds from sale and maturity of marketable securities 2,666.3 2,250.5 1,196.4
Purchases of property and equipment (389.2) (199.0) (180.0)
Acquisitions, net of cash acquired (30.2) 0.0 0.0
Other investing activities 10.1 (11.3) (1.2)
Net cash used in investing activities (216.1) (1,018.0) (1,015.2)
Financing activities      
Net proceeds from issuance of common stock 20.3 15.3 11.9
Proceeds from issuance of convertible notes, net of issuance costs 0.0 1,188.8 0.0
Repurchase of convertible notes 0.0 (282.6) 0.0
Other financing activities (9.9) (9.4) (1.2)
Net cash provided by financing activities 10.4 912.1 10.7
Effect of exchange rate changes on cash, cash equivalents and restricted cash (1.4) 2.1 (0.7)
Increase (decrease) in cash, cash equivalents and restricted cash 235.4 371.8 (690.7)
Cash, cash equivalents and restricted cash, beginning of period 818.2 446.4 1,137.1
Cash, cash equivalents and restricted cash, end of period 1,053.6 818.2 446.4
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Cash and cash equivalents 1,052.6 817.6 446.2
Restricted cash 1.0 0.6 0.2
Total cash, cash equivalents and restricted cash 1,053.6 818.2 446.4
Supplemental disclosure of non-cash investing and financing transactions:      
Shares issued for repurchase and conversions of senior convertible notes 157.7 1,350.9 0.0
Shares received under note hedge upon conversion of 2023 Notes (130.8) 0.0 0.0
Acquisition of property and equipment included in accounts payable and accrued liabilities 45.4 35.3 14.2
Supplemental cash flow information:      
Cash paid during the year for interest 11.6 10.6 10.4
Cash paid during the year for income taxes $ 16.8 $ 3.6 $ 4.8