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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Operating activities      
Net income $ 341.2 $ 216.9 [1],[2] $ 549.7 [1],[2]
Adjustments to reconcile net income to cash provided by operating activities:      
Depreciation and amortization 155.9 102.0 [2] 67.1 [2]
Share-based compensation 126.5 113.4 [2] 119.4 [2]
Collaborative research and development fee 0.0 87.1 [1],[2] 0.0 [1],[2]
Loss on extinguishment of debt 0.0 0.1 [1],[2] 0.0 [1],[2]
Non-cash interest expense 6.3 7.2 [2] 7.0 [2]
Realized (gain) loss on equity investment (0.2) (11.6) [2] 0.0 [2]
Deferred income taxes (including benefit from valuation allowance release) (21.6) 15.8 [2] (260.5) [2]
Other non-cash income and expenses 34.7 43.6 [2] 13.7 [2]
Changes in operating assets and liabilities:      
Accounts receivable, net (199.9) (75.5) [2] (142.3) [2]
Inventory 49.3 (112.2) [2] (114.5) [2]
Prepaid and other assets (131.6) (21.3) [2] (2.4) [2]
Operating lease right-of-use assets and liabilities, net (5.8) (0.1) [2] (0.8) [2]
Accounts payable and accrued liabilities 295.1 58.0 [2] 194.5 [2]
Accrued payroll and related expenses 8.5 10.4 [2] 26.1 [2]
Deferred revenue and other liabilities 11.1 8.7 [2] 18.6 [2]
Net cash provided by operating activities 669.5 442.5 [2] 475.6 [2]
Investing activities      
Purchase of marketable securities (2,266.3) (2,473.1) [2] (3,058.2) [2]
Proceeds from sale and maturity of marketable securities 2,127.8 2,666.3 [2] 2,250.5 [2]
Purchases of property and equipment (364.8) (389.2) [2] (199.0) [2]
Acquisitions, net of cash acquired (3.9) (30.2) [2] 0.0 [2]
Other investing activities (14.3) 10.1 [2] (11.3) [2]
Net cash used in investing activities (521.5) (216.1) [2] (1,018.0) [2]
Financing activities      
Net proceeds from issuance of common stock 22.5 20.3 [2] 15.3 [2]
Purchases of treasury stock (557.7) 0.0 [2] 0.0 [2]
Proceeds from issuance of convertible notes, net of issuance costs 0.0 0.0 [2] 1,188.8 [2]
Repurchase of convertible notes 0.0 0.0 [2] (282.6) [2]
Other financing activities (17.3) (9.9) [2] (9.4) [2]
Net cash provided by (used in) financing activities (552.5) 10.4 [2] 912.1 [2]
Effect of exchange rate changes on cash, cash equivalents and restricted cash (5.8) (1.4) [2] 2.1 [2]
Increase (decrease) in cash, cash equivalents and restricted cash (410.3) 235.4 [2] 371.8 [2]
Cash, cash equivalents and restricted cash, beginning of period [2] 1,053.6 818.2 446.4
Cash, cash equivalents and restricted cash, end of period 643.3 1,053.6 [2] 818.2 [2]
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Cash and cash equivalents 642.3 1,052.6 [2],[3] 817.6 [2]
Restricted cash 1.0 1.0 [2] 0.6 [2]
Total cash, cash equivalents and restricted cash 643.3 1,053.6 [2] 818.2 [2]
Supplemental disclosure of non-cash investing and financing transactions:      
Shares issued for repurchase and conversions of senior convertible notes 35.9 157.7 [2] 1,350.9 [2]
Shares received under note hedge upon conversion of 2023 Notes (33.5) (130.8) [2] 0.0 [2]
Acquisition of property and equipment included in accounts payable and accrued liabilities 25.7 45.4 [2] 35.3 [2]
Supplemental cash flow information:      
Cash paid during the year for interest 12.2 11.6 [2] 10.6 [2]
Cash paid during the year for income taxes $ 114.2 $ 16.8 [2] $ 3.6 [2]
[1] * We adjusted our 2021 and 2020 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. All periods presented have also been adjusted to reflect the four-for-one stock split. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.
[2] * We adjusted our 2021 and 2020 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.
[3] * We adjusted our 2021 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. All periods presented have also been adjusted to reflect the four-for-one stock split. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.