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Income Taxes - Schedule of Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021		Dec. 31, 2020
Effective Income Tax Rate Reconciliation, Amount [Abstract]
U.S. federal statutory tax rate	$ 82.1	$ 53.9		$ 62.6
State income tax, net of federal benefit	5.4	8.9		5.3
Permanent items	0.6	5.2		2.6
Research and development credits	(23.3)	(28.9)		(24.4)
Foreign tax credit	0.0	(3.7)		0.0
Foreign rate differential	27.7	20.9		9.8
Stock and officers compensation	(1.2)	(20.4)		(28.7)
Collaboration agreement milestone share-based payment	(52.9)	0.0		0.0
Change in statutory tax rates	1.0	(10.0)		(4.1)
Other	1.3	(0.4)		0.1
Change in valuation allowance	8.9	14.4		(275.0)
Income taxes at effective rates	$ 49.6	$ 39.9	[1]	$ (251.8)	[1]
[1] * We adjusted our 2021 and 2020 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. All periods presented have also been adjusted to reflect the four-for-one stock split. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.

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