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Consolidated Statements of Operations - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
 [1]
Dec. 31, 2020
 [1]
Income Statement [Abstract]      
Revenue $ 2,909.8 $ 2,448.5 $ 1,926.7
Cost of sales 1,026.7 768.0 646.6
Gross profit 1,883.1 1,680.5 1,280.1
Operating expenses:      
Research and development 484.2 517.1 359.9
Collaborative research and development fee 0.0 87.1 [2] 0.0 [2]
Amortization of intangible assets 7.5 3.7 2.5
Selling, general and administrative 1,000.2 806.8 618.2
Total operating expenses 1,491.9 1,414.7 980.6
Operating income 391.2 265.8 299.5
Interest expense (18.6) (18.8) (17.7)
Loss on extinguishment of debt 0.0 (0.1) [2] 0.0 [2]
Income from equity investments 0.2 11.6 0.0
Interest and other income (expense), net 18.0 (1.7) 16.1
Income before income taxes 390.8 256.8 297.9
Income tax expense (benefit) 49.6 39.9 (251.8)
Net income $ 341.2 $ 216.9 [2] $ 549.7 [2]
Basic net income per share (usd per share) $ 0.88 $ 0.56 $ 1.46
Shares used to compute basic net income per share (in shares) 389.4 386.9 377.5
Diluted net income per share (usd per share) $ 0.82 $ 0.53 $ 1.33
Shares used to compute diluted net income per share (in shares) 427.5 428.8 420.4
[1] * We adjusted our 2021 and 2020 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. All periods presented have also been adjusted to reflect the four-for-one stock split. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.
[2] * We adjusted our 2021 and 2020 amounts to reflect the simplified convertible instruments accounting guidance, which we adopted on a full retrospective basis. Refer to Note 1, “Organization and Significant Accounting Policies,” to the consolidated financial statements for further information.