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Income Taxes - Schedule of Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Effective Income Tax Rate Reconciliation, Amount [Abstract]      
U.S. federal statutory tax rate $ 149.2 $ 82.1 $ 53.9
State income tax, net of federal benefit 7.8 5.4 8.9
Permanent items (2.7) 0.6 5.2
Research and development credits (28.3) (23.3) (28.9)
Foreign tax credit 0.0 0.0 (3.7)
Foreign rate differential 15.8 27.7 20.9
Stock and officers compensation 5.6 (1.2) (20.4)
Collaboration agreement milestone share-based payment (72.1) (52.9) 0.0
Change in statutory tax rates 19.4 1.0 (10.0)
Intellectual property transfer 63.9 0.0 0.0
Other 0.3 1.3 (0.4)
Change in valuation allowance 10.0 8.9 14.4
Income taxes at effective rates $ 168.9 $ 49.6 $ 39.9