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Consolidated Statements of Cash Flows - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating activities      
Net income $ 541.5 $ 341.2 $ 216.9
Adjustments to reconcile net income to cash provided by operating activities:      
Depreciation and amortization 186.0 155.9 102.0
Share-based compensation 150.8 126.5 113.4
Collaborative research and development fee 0.0 0.0 87.1
Loss on extinguishment of debt 0.0 0.0 0.1
Non-cash interest expense 7.8 6.3 7.2
Realized (gain) loss on equity investment (1.9) (0.2) (11.6)
Deferred income taxes (55.0) (21.6) 15.8
Other non-cash income and expenses (83.9) 34.7 43.6
Changes in operating assets and liabilities:      
Accounts receivable, net (260.1) (199.9) (75.5)
Inventory (252.6) 49.3 (112.2)
Prepaid and other assets 19.3 (131.6) (21.3)
Operating lease right-of-use assets and liabilities, net (4.5) (5.8) (0.1)
Accounts payable and accrued liabilities 466.5 295.1 58.0
Accrued payroll and related expenses 37.2 8.5 10.4
Deferred revenue and other liabilities (2.6) 11.1 8.7
Net cash provided by operating activities 748.5 669.5 442.5
Investing activities      
Purchase of marketable securities (3,200.4) (2,266.3) (2,473.1)
Proceeds from sale and maturity of marketable securities 2,947.4 2,127.8 2,666.3
Purchases of property and equipment (236.6) (364.8) (389.2)
Acquisitions, net of cash acquired 0.0 (3.9) (30.2)
Other investing activities (17.6) (14.3) 10.1
Net cash used in investing activities (507.2) (521.5) (216.1)
Financing activities      
Net proceeds from issuance of common stock 26.6 22.5 20.3
Purchases of treasury stock (688.7) (557.7) 0.0
Proceeds from issuance of convertible notes, net of issuance costs 1,230.6 0.0 0.0
Purchases of capped call transactions (101.3) 0.0 0.0
Payments for conversions of senior convertible notes (787.3) 0.0 0.0
Other financing activities 1.5 (17.3) (9.9)
Net cash provided by (used in) financing activities (318.6) (552.5) 10.4
Effect of exchange rate changes on cash, cash equivalents and restricted cash 1.5 (5.8) (1.4)
Increase (decrease) in cash, cash equivalents and restricted cash (75.8) (410.3) 235.4
Cash, cash equivalents and restricted cash, beginning of period 643.3 1,053.6 818.2
Cash, cash equivalents and restricted cash, end of period 567.5 643.3 1,053.6
Reconciliation of cash, cash equivalents and restricted cash, end of period:      
Cash and cash equivalents 566.3 642.3 1,052.6
Restricted cash 1.2 1.0 1.0
Total cash, cash equivalents and restricted cash 567.5 643.3 1,053.6
Supplemental disclosure of non-cash investing and financing transactions:      
Shares issued for repurchase and conversions of senior convertible notes 1,501.9 35.9 157.7
Shares received under note hedge upon conversion of 2023 Notes (1,490.3) (33.5) (130.8)
Acquisition of property and equipment included in accounts payable and accrued liabilities 53.2 25.7 45.4
Supplemental cash flow information:      
Cash paid during the year for interest 12.4 12.2 11.6
Cash paid during the year for income taxes $ 212.3 $ 114.2 $ 16.8