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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2023
Income Tax Disclosure [Abstract]  
Schedule of Income (Loss) before Income Taxes Subject to Taxes
Income (loss) before income taxes subject to taxes in the following jurisdictions is as follows:
Twelve Months Ended
December 31,
(In millions)
202320222021
United States$732.4 $463.5 $318.2 
Outside of the United States(22.0)(72.7)(61.4)
Total$710.4 $390.8 $256.8 
Schedule of Components of Income Tax Expense (Benefit)
Significant components of the provision for income taxes are as follows:
Twelve Months Ended
December 31,
(In millions)
202320222021
Current:
Federal$149.1 $32.6 $5.7 
State18.1 26.1 8.3 
Foreign56.7 12.5 10.1 
Total current income taxes223.9 71.2 24.1 
Deferred:
Federal(93.7)(4.3)23.0 
State14.6 (17.6)(0.2)
Foreign24.1 0.3 (7.0)
Total deferred income taxes(55.0)(21.6)15.8 
Total$168.9 $49.6 $39.9 
Schedule of Tax Credit Carryforwards
Significant loss and tax credit carryforwards and years of expiration are as follows:
December 31,Year of Expiration
(In millions)20232022
Net operating loss:
Federal$20.4 $28.7 2028
California167.7 185.0 2032
Other states7.8 8.5 2028
UK— 90.5 Indefinite
Other foreign6.0 9.7 
2027
Tax credits:
Federal
R&D credits— — 
Foreign tax credits0.1 — 
California R&D credits111.9 96.4 Indefinite
California AMT Credits
$0.5 $— Indefinite
Schedule of Operating Loss Carryforwards
Significant loss and tax credit carryforwards and years of expiration are as follows:
December 31,Year of Expiration
(In millions)20232022
Net operating loss:
Federal$20.4 $28.7 2028
California167.7 185.0 2032
Other states7.8 8.5 2028
UK— 90.5 Indefinite
Other foreign6.0 9.7 
2027
Tax credits:
Federal
R&D credits— — 
Foreign tax credits0.1 — 
California R&D credits111.9 96.4 Indefinite
California AMT Credits
$0.5 $— Indefinite
Schedule of Deferred Tax Assets and Liabilities
December 31,
(In millions)20232022
Deferred tax assets:
Net operating loss carryforwards$18.1 $46.4 
Capitalized research and development expenses233.4 211.9 
Tax credits71.4 61.1 
Share-based compensation27.0 16.8 
Fixed and intangible assets279.8 34.4 
Accrued liabilities and reserves91.0 105.3 
Convertible debt20.6 9.3 
Total gross deferred tax assets741.3 485.2 
Less: valuation allowance(264.3)(78.7)
Total net deferred tax assets477.0 406.5 
Deferred tax liabilities:
Fixed assets and acquired intangibles assets(60.4)(69.9)
Other— (0.3)
Total deferred tax liabilities(60.4)(70.2)
Net deferred tax assets (liabilities)$416.6 $336.3 
Schedule of Reconciliation between Effective Tax Rate and Statutory Rate
The reconciliation between our effective tax rate on income (loss) from continuing operations and the statutory rate is as follows:
Twelve Months Ended
December 31,
(In millions)202320222021
U.S. federal statutory tax rate$149.2 $82.1 $53.9 
State income tax, net of federal benefit7.8 5.4 8.9 
Permanent items(2.7)0.6 5.2 
Research and development credits(28.3)(23.3)(28.9)
Foreign tax credit— — (3.7)
Foreign rate differential15.8 27.7 20.9 
Stock and officers compensation5.6 (1.2)(20.4)
Collaboration agreement milestone share-based payment(72.1)(52.9)— 
Change in statutory tax rates19.4 1.0 (10.0)
Intellectual property transfer
63.9 — — 
Other0.3 1.3 (0.4)
Change in valuation allowance10.0 8.9 14.4 
Income taxes at effective rates
$168.9 $49.6 $39.9 
Schedule of Unrecognized Tax Benefits
The following table summarizes the activity related to our gross unrecognized tax benefits:
(In millions)
Balance at January 1, 2021
$36.6 
Increases related to prior year tax positions
0.4 
Increases related to current year tax positions
9.8 
Balance at December 31, 202146.8 
Decreases related to prior year tax positions
(0.9)
Increases related to current year tax positions
6.1 
Balance at December 31, 202252.0 
Increases related to prior year tax positions
0.8 
Increases related to current year tax positions
6.6 
Balance at December 31, 2023$59.4 
Schedule of Years Remaining Subject to Audit by Major Jurisdiction The years remaining subject to audit, by major jurisdiction, are as follows:
JurisdictionFiscal Year
United States (Federal and state)
1999 - 2023
Germany
2019 - 2023
United Kingdom
2020 - 2023
Canada
2019 - 2023
Malaysia
2021 - 2023