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Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 14.4 | $ 18.1
Capitalized research and development expenses | 265.0 | 233.4
Tax credits | 79.2 | 71.4
Share-based compensation | 22.5 | 27.0
Fixed and intangible assets | 263.6 | 279.8
Accrued liabilities and reserves | 87.4 | 91.0
Convertible debt | 16.0 | 20.6
Total gross deferred tax assets | 748.1 | 741.3
Less: valuation allowance | (221.9) | (264.3)
Total net deferred tax assets | 526.2 | 477.0
Deferred tax liabilities: |  |
Fixed assets and acquired intangibles assets | (59.3) | (60.4)
Other | (0.3) | 0.0
Total deferred tax liabilities | (59.6) | (60.4)
Net deferred tax assets (liabilities) | $ 466.6 | $ 416.6

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