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Income Taxes - Schedule of Reconciliation between Effective Tax Rate and Statutory Rate (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Effective Income Tax Rate Reconciliation, Amount [Abstract]      
U.S. federal statutory tax rate $ 148.9 $ 149.2 $ 82.1
State income tax, net of federal benefit 10.2 7.8 5.4
Permanent items 10.5 (2.7) 0.6
Research and development credits (24.6) (28.3) (23.3)
Foreign tax credit (1.2) 0.0 0.0
Foreign rate differential 1.6 15.8 27.7
Stock and officers compensation 3.8 5.6 (1.2)
Collaboration agreement milestone share-based payment (32.2) (72.1) (52.9)
Change in statutory tax rates 51.5 19.4 1.0
Intellectual property transfer 0.0 63.9 0.0
Other 6.7 0.3 1.3
Change in valuation allowance (42.4) 10.0 8.9
Income taxes at effective rates $ 132.8 $ 168.9 $ 49.6