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Organization and Significant Accounting Policies - Earnings Per Share, Basic and Diluted (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Net income $ 283.8 $ 134.6 $ 569.0 $ 424.5
Add back interest expense, net of tax attributable to assumed conversion of senior convertible notes 2.8 2.9 8.6 8.7
Net income - diluted $ 286.6 $ 137.5 $ 577.6 $ 433.2
Net income per common share        
Basic (in USD per share) $ 0.73 $ 0.34 $ 1.45 $ 1.08
Diluted (in USD per share) $ 0.70 $ 0.34 $ 1.42 $ 1.04
Basic weighted average shares outstanding (in shares) 391.1 394.2 391.4 394.6
Diluted weighted average shares outstanding (in shares) 407.4 410.2 407.7 414.7
Collaborative sales-based milestones        
Net income per common share        
Dilutive potential securities (in shares) 0.0 0.0 0.0 0.3
RSUs and PSUs        
Net income per common share        
Dilutive potential securities (in shares) 0.6 0.3 0.6 0.7
Senior convertible notes        
Net income per common share        
Dilutive potential securities (in shares) 15.7 15.7 15.7 15.7
Warrants        
Net income per common share        
Dilutive potential securities (in shares) 0.0 0.0 0.0 3.4