<SEC-DOCUMENT>0001415889-23-009372.txt : 20230607
<SEC-HEADER>0001415889-23-009372.hdr.sgml : 20230607
<ACCEPTANCE-DATETIME>20230607165559
ACCESSION NUMBER:		0001415889-23-009372
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20230605
FILED AS OF DATE:		20230607
DATE AS OF CHANGE:		20230607

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Isaacson Christopher A
		CENTRAL INDEX KEY:			0001538451

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34774
		FILM NUMBER:		23999654

	MAIL ADDRESS:	
		STREET 1:		433 WEST VAN BUREN STREET
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60607

	FORMER NAME:	
		FORMER CONFORMED NAME:	Isaacson Chris A
		DATE OF NAME CHANGE:	20111229

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cboe Global Markets, Inc.
		CENTRAL INDEX KEY:			0001374310
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		IRS NUMBER:				205446972
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		433 WEST VAN BUREN STREET
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60607
		BUSINESS PHONE:		312 786 7200

	MAIL ADDRESS:	
		STREET 1:		433 WEST VAN BUREN STREET
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60607

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CBOE Holdings, Inc.
		DATE OF NAME CHANGE:	20060831
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>form4-06072023_080650.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0407</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2023-06-05</periodOfReport>

    <issuer>
        <issuerCik>0001374310</issuerCik>
        <issuerName>Cboe Global Markets, Inc.</issuerName>
        <issuerTradingSymbol>CBOE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001538451</rptOwnerCik>
            <rptOwnerName>Isaacson Christopher A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CBOE GLOBAL MARKETS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>433 WEST VAN BUREN STREET</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60607</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>EVP, COO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2023-06-05</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3850</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>133.98</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>61349</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 28, 2023.</footnote>
        <footnote id="F2">Includes 312 shares purchased pursuant to the Cboe Global Markets, Inc. Employee Stock Purchase Plan (&quot;ESPP&quot;) on March 15, 2023, for the purchase period of September 16, 2022 to March 15, 2023. In accordance with the ESPP, these shares were purchased at a price equal to 85% of the lower of the closing price of the Issuer's common stock on September 16, 2022 or March 15, 2023.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Patrick Sexton</signatureName>
        <signatureDate>2023-06-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
