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  <xs:element id="mtd_February2019CrossCurrencySwapMember" abstract="true" name="February2019CrossCurrencySwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_ScheduleOfNetSalesSegmentProfitAndGoodwillBySegmentTableTextBlock" abstract="false" name="ScheduleOfNetSalesSegmentProfitAndGoodwillBySegmentTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
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  <xs:element id="mtd_NonServicePensionCostsBenefits" abstract="false" name="NonServicePensionCostsBenefits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mtd_June20214YRCrossCurrencySwapMember" abstract="true" name="June20214YRCrossCurrencySwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_A1.30EuroSeniorNotesMember" abstract="true" name="A1.30EuroSeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_LoanfromSwissPensionPlanUSDAmount" abstract="false" name="LoanfromSwissPensionPlanUSDAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mtd_ExciseTaxOnNetRepurchasesOfCommonStock" abstract="false" name="ExciseTaxOnNetRepurchasesOfCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mtd_LaboratoryproductsandservicesMember" abstract="true" name="LaboratoryproductsandservicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_A291SeniorNoteMember" abstract="true" name="A291SeniorNoteMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_SharesRepurchasedUnderShareRepurchaseProgram" abstract="false" name="SharesRepurchasedUnderShareRepurchaseProgram" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="mtd_A4.10SeniorNotesMember" abstract="true" name="A4.10SeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_A106EuroSeniorNotesMember" abstract="true" name="A106EuroSeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_ChineseOperationsMember" abstract="true" name="ChineseOperationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_A4.24SeniorNotesMember" abstract="true" name="A4.24SeniorNotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_June20213YRCrossCurrencySwapMember" abstract="true" name="June20213YRCrossCurrencySwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_LineOfCreditFacilityForecastedBorrowingAmount" abstract="false" name="LineOfCreditFacilityForecastedBorrowingAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mtd_ShareRepurchaseProgramAndTreasuryStockTextualsAbstract" abstract="true" name="ShareRepurchaseProgramAndTreasuryStockTextualsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="mtd_SwissPensionLoansMember" abstract="true" name="SwissPensionLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_RetailproductsandservicesMember" abstract="true" name="RetailproductsandservicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="mtd_InterestRateSwapShortTerm" abstract="false" name="InterestRateSwapShortTerm" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="mtd_OtherLocalArrangementsMember" abstract="true" name="OtherLocalArrangementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="mtd_PurchasedIntangibleAmortizationGross" abstract="false" name="PurchasedIntangibleAmortizationGross" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mtd_ChangeinCarryingValueVerseFairValueofLongTermDebt" abstract="false" name="ChangeinCarryingValueVerseFairValueofLongTermDebt" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="mtd_June20192YRCrossCurrencySwapMember" abstract="true" name="June20192YRCrossCurrencySwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
