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<!--XBRL Document Created with Wdesk from Workiva-->
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_498cc9f6-f2a0-45d7-9d1e-339170b81886_verboseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt securities available for sale</link:label>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
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    <link:label id="lab_us-gaap_HedgingDesignationDomain_c1fd66dd-4855-4001-9d50-da6834dc1979_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:label id="lab_us-gaap_HedgingDesignationDomain_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationDomain" xlink:to="lab_us-gaap_HedgingDesignationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_MaximumQuantifiableFannieMaeDUSLossShareGuarantee_3447bf42-7bb4-463a-bf9d-3fdd990b1ef0_terseLabel_en-US" xlink:label="lab_rf_MaximumQuantifiableFannieMaeDUSLossShareGuarantee" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum Quantifiable Fannie Mae DUS Loss Share Guarantee</link:label>
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    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_757754c2-59e8-44e2-b02e-346260458483_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
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    <link:label id="lab_rf_CommercialAndIndustrialMember_0fa7adf1-f4b9-4e0a-a411-73fb48ed9003_terseLabel_en-US" xlink:label="lab_rf_CommercialAndIndustrialMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial And Industrial [Member]</link:label>
    <link:label id="lab_rf_CommercialAndIndustrialMember_label_en-US" xlink:label="lab_rf_CommercialAndIndustrialMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial And Industrial [Member]</link:label>
    <link:label id="lab_rf_CommercialAndIndustrialMember_documentation_en-US" xlink:label="lab_rf_CommercialAndIndustrialMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial and industrial [Member]</link:label>
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    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_9d48d2ca-4216-4f3f-b9a2-9be26abad9d7_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
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    <link:label id="lab_dei_EntityAddressStateOrProvince_67432817-6c40-434e-8f0d-2e6365c4ddb2_terseLabel_en-US" xlink:label="lab_dei_EntityAddressStateOrProvince" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, State or Province</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressStateOrProvince" xlink:to="lab_dei_EntityAddressStateOrProvince" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_dde84818-6251-46c8-829c-d925491a61bd_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Level 1 [Member]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
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    <link:label id="lab_us-gaap_PledgedStatusAxis_7efec18f-a7d2-4a5d-8760-ed91b5e3c5e2_terseLabel_en-US" xlink:label="lab_us-gaap_PledgedStatusAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Status [Axis]</link:label>
    <link:label id="lab_us-gaap_PledgedStatusAxis_label_en-US" xlink:label="lab_us-gaap_PledgedStatusAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Status [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PledgedStatusAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PledgedStatusAxis" xlink:to="lab_us-gaap_PledgedStatusAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AllowanceForLoanAndLeaseLossesAdjustmentsNet_0b4d2661-91a7-4cc1-a644-e8afd1c559f0_terseLabel_en-US" xlink:label="lab_us-gaap_AllowanceForLoanAndLeaseLossesAdjustmentsNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase in Allowance at Modification</link:label>
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    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSales_4219101b-1e19-4719-be6b-fc194535d94a_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSales" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sales</link:label>
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    <link:label id="lab_us-gaap_OtherInterestAndDividendIncome_718f3644-ec3c-4675-926d-a368814c66f0_terseLabel_en-US" xlink:label="lab_us-gaap_OtherInterestAndDividendIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other earning assets</link:label>
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    <link:label id="lab_us-gaap_ServicingAssetAtFairValueAmount_48b80238-d9e7-41fe-aad7-3d2a1a8c421e_verboseLabel_en-US" xlink:label="lab_us-gaap_ServicingAssetAtFairValueAmount" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential mortgage servicing rights at fair value</link:label>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_128da6a1-5c35-41ed-899c-5d624a62a242_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash from operating activities</link:label>
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    <link:label id="lab_us-gaap_ObligationsMember_6630bc9a-d8e2-4b61-bb80-9b10fe2304e0_terseLabel_en-US" xlink:label="lab_us-gaap_ObligationsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Obligations</link:label>
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    <link:label id="lab_us-gaap_LoansNotesTradeAndOtherReceivablesDisclosureTextBlock_1d632abc-82d4-452e-93cd-536e6ab043a9_terseLabel_en-US" xlink:label="lab_us-gaap_LoansNotesTradeAndOtherReceivablesDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans and the Allowance for Credit Losses</link:label>
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    <link:label id="lab_us-gaap_Liabilities_94720d6d-e733-426f-963f-a21fbdf6b112_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_Liabilities_label_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities" xlink:to="lab_us-gaap_Liabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_dd2d69e9-77c6-43c4-983d-3a3edf445484_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investing activities:</link:label>
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    <link:label id="lab_us-gaap_CreditScoreFicoDomain_1c64a73a-c617-4906-b78d-d3497953d3df_terseLabel_en-US" xlink:label="lab_us-gaap_CreditScoreFicoDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Score, FICO [Domain]</link:label>
    <link:label id="lab_us-gaap_CreditScoreFicoDomain_label_en-US" xlink:label="lab_us-gaap_CreditScoreFicoDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Credit Score, FICO [Domain]</link:label>
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    <link:label id="lab_rf_TotalCompanyMember_7c8e453d-d8b7-40d5-a94c-c60c635b6c28_terseLabel_en-US" xlink:label="lab_rf_TotalCompanyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consolidated [Member]</link:label>
    <link:label id="lab_rf_TotalCompanyMember_label_en-US" xlink:label="lab_rf_TotalCompanyMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Company [Member]</link:label>
    <link:label id="lab_rf_TotalCompanyMember_documentation_en-US" xlink:label="lab_rf_TotalCompanyMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Company [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_TotalCompanyMember" xlink:href="rf-20220630.xsd#rf_TotalCompanyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_TotalCompanyMember" xlink:to="lab_rf_TotalCompanyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_NonAccrualMember_6041a9aa-89c3-4ebb-9365-327e34544a9f_terseLabel_en-US" xlink:label="lab_rf_NonAccrualMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non Accrual [Member]</link:label>
    <link:label id="lab_rf_NonAccrualMember_label_en-US" xlink:label="lab_rf_NonAccrualMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non Accrual [Member]</link:label>
    <link:label id="lab_rf_NonAccrualMember_documentation_en-US" xlink:label="lab_rf_NonAccrualMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-Accrual [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_NonAccrualMember" xlink:href="rf-20220630.xsd#rf_NonAccrualMember"/>
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    <link:label id="lab_rf_ForwardRateCommitmentsandFuturesContractsMember_a56e8bee-12a1-4d6b-8756-0315e4b887b4_terseLabel_en-US" xlink:label="lab_rf_ForwardRateCommitmentsandFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forward Rate Commitments and Futures Contracts [Member]</link:label>
    <link:label id="lab_rf_ForwardRateCommitmentsandFuturesContractsMember_label_en-US" xlink:label="lab_rf_ForwardRateCommitmentsandFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forward Rate Commitments and Futures Contracts [Member]</link:label>
    <link:label id="lab_rf_ForwardRateCommitmentsandFuturesContractsMember_documentation_en-US" xlink:label="lab_rf_ForwardRateCommitmentsandFuturesContractsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forward Rate Commitments and Futures Contracts [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_ForwardRateCommitmentsandFuturesContractsMember" xlink:href="rf-20220630.xsd#rf_ForwardRateCommitmentsandFuturesContractsMember"/>
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    <link:label id="lab_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_3b94ceed-89a7-4e0e-9612-5edb85349582_terseLabel_en-US" xlink:label="lab_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans held for sale</link:label>
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    <link:label id="lab_rf_InterestRateFuturesAndForwardCommitmentsMember_documentation_en-US" xlink:label="lab_rf_InterestRateFuturesAndForwardCommitmentsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Futures And Forward Commitments [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_InterestRateFuturesAndForwardCommitmentsMember" xlink:href="rf-20220630.xsd#rf_InterestRateFuturesAndForwardCommitmentsMember"/>
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    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_ad725754-27e7-4aeb-bfa9-c5dcec03cf87_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
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    <link:label id="lab_rf_HedgedAssetFairValuePortfolioLayerAmount_documentation_en-US" xlink:label="lab_rf_HedgedAssetFairValuePortfolioLayerAmount" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedged Asset, Fair Value, Portfolio Layer, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_HedgedAssetFairValuePortfolioLayerAmount" xlink:href="rf-20220630.xsd#rf_HedgedAssetFairValuePortfolioLayerAmount"/>
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    <link:label id="lab_us-gaap_IncreaseDecreaseInDeposits_0f10578d-d500-47a1-8688-335bed9499dd_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeposits" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net change in deposits</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeposits" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDeposits"/>
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    <link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_38634ef8-17fa-4f47-b669-cf4977cb6cd1_terseLabel_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Segments [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementBusinessSegmentsAxis_label_en-US" xlink:label="lab_us-gaap_StatementBusinessSegmentsAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Segments [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
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    <link:label id="lab_rf_ResidentialNonAgencyMember_e308b863-5614-4a85-8220-56ae3fb32b5b_terseLabel_en-US" xlink:label="lab_rf_ResidentialNonAgencyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential Non-Agency [Member]</link:label>
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    <link:label id="lab_rf_ResidentialNonAgencyMember_documentation_en-US" xlink:label="lab_rf_ResidentialNonAgencyMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential Non agency [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_ResidentialNonAgencyMember" xlink:href="rf-20220630.xsd#rf_ResidentialNonAgencyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_ResidentialNonAgencyMember" xlink:to="lab_rf_ResidentialNonAgencyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_ProductsAndServicesDomain_0d500e61-8334-40e5-bbe2-89086c54c94a_terseLabel_en-US" xlink:label="lab_srt_ProductsAndServicesDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Domain]</link:label>
    <link:label id="lab_srt_ProductsAndServicesDomain_label_en-US" xlink:label="lab_srt_ProductsAndServicesDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_ProductsAndServicesDomain" xlink:to="lab_srt_ProductsAndServicesDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityShellCompany_dfc52202-c4e4-4415-a21b-0091540a8045_terseLabel_en-US" xlink:label="lab_dei_EntityShellCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Shell Company</link:label>
    <link:label id="lab_dei_EntityShellCompany_label_en-US" xlink:label="lab_dei_EntityShellCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Shell Company</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
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    <link:label id="lab_us-gaap_PaymentsToAcquireOtherProductiveAssets_5330d045-a736-4c1d-b8d7-0f9b8c0fe0a0_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireOtherProductiveAssets" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net purchases of other assets</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireOtherProductiveAssets_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireOtherProductiveAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Other Productive Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireOtherProductiveAssets" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireOtherProductiveAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireOtherProductiveAssets" xlink:to="lab_us-gaap_PaymentsToAcquireOtherProductiveAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_CommercialinvestorrealestatemortgageMember_688b4c30-c8eb-492a-abf5-662419b3b00c_terseLabel_en-US" xlink:label="lab_rf_CommercialinvestorrealestatemortgageMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial investor real estate mortgage [Member]</link:label>
    <link:label id="lab_rf_CommercialinvestorrealestatemortgageMember_label_en-US" xlink:label="lab_rf_CommercialinvestorrealestatemortgageMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial investor real estate mortgage [Member]</link:label>
    <link:label id="lab_rf_CommercialinvestorrealestatemortgageMember_documentation_en-US" xlink:label="lab_rf_CommercialinvestorrealestatemortgageMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial investor real estate mortgage [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_CommercialinvestorrealestatemortgageMember" xlink:href="rf-20220630.xsd#rf_CommercialinvestorrealestatemortgageMember"/>
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    <link:label id="lab_rf_HedgingInstrumentAxis_be0670a0-4ae6-4120-ba0c-db9f70829ffa_terseLabel_en-US" xlink:label="lab_rf_HedgingInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Instrument [Axis]</link:label>
    <link:label id="lab_rf_HedgingInstrumentAxis_label_en-US" xlink:label="lab_rf_HedgingInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Instrument [Axis]</link:label>
    <link:label id="lab_rf_HedgingInstrumentAxis_documentation_en-US" xlink:label="lab_rf_HedgingInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_HedgingInstrumentAxis" xlink:href="rf-20220630.xsd#rf_HedgingInstrumentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_HedgingInstrumentAxis" xlink:to="lab_rf_HedgingInstrumentAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_CommercialAgencyMember_03250bc9-82a1-4725-a160-d23f823462ba_terseLabel_en-US" xlink:label="lab_rf_CommercialAgencyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Agency [Member]</link:label>
    <link:label id="lab_rf_CommercialAgencyMember_label_en-US" xlink:label="lab_rf_CommercialAgencyMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Agency [Member]</link:label>
    <link:label id="lab_rf_CommercialAgencyMember_documentation_en-US" xlink:label="lab_rf_CommercialAgencyMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Agency [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_CommercialAgencyMember" xlink:href="rf-20220630.xsd#rf_CommercialAgencyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_CommercialAgencyMember" xlink:to="lab_rf_CommercialAgencyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock_3bce76fe-4a90-4ddd-9d1f-71ec8c63ec82_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfPreferredStockAndPreferenceStock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Preferred Stock and Preference Stock</link:label>
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    <link:label id="lab_rf_ServicingAssetAtFairValuePurchases_2fb775bd-5ba4-452e-847e-9bf41eb484ba_terseLabel_en-US" xlink:label="lab_rf_ServicingAssetAtFairValuePurchases" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases</link:label>
    <link:label id="lab_rf_ServicingAssetAtFairValuePurchases_label_en-US" xlink:label="lab_rf_ServicingAssetAtFairValuePurchases" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Servicing Asset, at fair value, purchases</link:label>
    <link:label id="lab_rf_ServicingAssetAtFairValuePurchases_documentation_en-US" xlink:label="lab_rf_ServicingAssetAtFairValuePurchases" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Servicing asset, at fair value, purchases</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_ServicingAssetAtFairValuePurchases" xlink:href="rf-20220630.xsd#rf_ServicingAssetAtFairValuePurchases"/>
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    <link:label id="lab_us-gaap_FinancialInstrumentAxis_2fbe3f4d-0da8-4f49-978a-510d0e51af3b_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentAxis" xlink:to="lab_us-gaap_FinancialInstrumentAxis" xlink:type="arc" order="1"/>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventMember" xlink:to="lab_us-gaap_SubsequentEventMember" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentPeriodEndDate_826afb59-a497-452f-a34b-ab6bfa8f70ad_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Period End Date</link:label>
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    <link:label id="lab_us-gaap_DerivativeNetLiabilityPositionAggregateFairValue_895e441e-0228-4531-b22e-6604461204dc_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeNetLiabilityPositionAggregateFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate fair value of all derivative instruments with credit risk</link:label>
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    <link:label id="lab_us-gaap_SeriesCPreferredStockMember_db4f5595-575e-461c-b941-1c7b630d5946_terseLabel_en-US" xlink:label="lab_us-gaap_SeriesCPreferredStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series C Preferred Stock [Member]</link:label>
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    <link:label id="lab_us-gaap_AvailableforsaleSecuritiesMember_f8f0e0de-a973-4294-8c7c-024771ee7fae_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableforsaleSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Available-for-sale Securities [Member]</link:label>
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    <link:label id="lab_us-gaap_ServicingAssetsAtFairValueLineItems_label_en-US" xlink:label="lab_us-gaap_ServicingAssetsAtFairValueLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Servicing Assets at Fair Value [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetsAtFairValueLineItems" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingAssetsAtFairValueLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ServicingAssetsAtFairValueLineItems" xlink:to="lab_us-gaap_ServicingAssetsAtFairValueLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_FannieMaeDUSServicingPortfolioAmount_38c3067e-66d5-4458-823b-4248ba18f7f6_terseLabel_en-US" xlink:label="lab_rf_FannieMaeDUSServicingPortfolioAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fannie Mae DUS Servicing Portfolio, Amount</link:label>
    <link:label id="lab_rf_FannieMaeDUSServicingPortfolioAmount_label_en-US" xlink:label="lab_rf_FannieMaeDUSServicingPortfolioAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fannie Mae DUS Servicing Portfolio, Amount</link:label>
    <link:label id="lab_rf_FannieMaeDUSServicingPortfolioAmount_documentation_en-US" xlink:label="lab_rf_FannieMaeDUSServicingPortfolioAmount" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fannie Mae DUS Servicing Portfolio, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_FannieMaeDUSServicingPortfolioAmount" xlink:href="rf-20220630.xsd#rf_FannieMaeDUSServicingPortfolioAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_FannieMaeDUSServicingPortfolioAmount" xlink:to="lab_rf_FannieMaeDUSServicingPortfolioAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_MortgageloansheldforsaleMember_4a6745b4-a307-4683-a8d5-380a6747234b_terseLabel_en-US" xlink:label="lab_rf_MortgageloansheldforsaleMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage loans held for sale [Member]</link:label>
    <link:label id="lab_rf_MortgageloansheldforsaleMember_label_en-US" xlink:label="lab_rf_MortgageloansheldforsaleMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage loans held for sale [Member]</link:label>
    <link:label id="lab_rf_MortgageloansheldforsaleMember_documentation_en-US" xlink:label="lab_rf_MortgageloansheldforsaleMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage loans held for sale [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_MortgageloansheldforsaleMember" xlink:href="rf-20220630.xsd#rf_MortgageloansheldforsaleMember"/>
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    <link:label id="lab_us-gaap_PastDueFinancingReceivablesTableTextBlock_9765f053-8727-4037-ae14-7fa5591ee70d_terseLabel_en-US" xlink:label="lab_us-gaap_PastDueFinancingReceivablesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Past Due Financing Receivables</link:label>
    <link:label id="lab_us-gaap_PastDueFinancingReceivablesTableTextBlock_label_en-US" xlink:label="lab_us-gaap_PastDueFinancingReceivablesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, Past Due [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PastDueFinancingReceivablesTableTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PastDueFinancingReceivablesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PastDueFinancingReceivablesTableTextBlock" xlink:to="lab_us-gaap_PastDueFinancingReceivablesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_d62fe79c-644b-4d59-b031-bd4f4d9d4d98_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest receivable and other assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Other Operating Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets"/>
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    <link:label id="lab_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable_14c11ddb-1ddf-4cbe-8723-70c11d39aa32_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Held-to-maturity [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Held-to-Maturity [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfHeldToMaturitySecuritiesTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable" xlink:to="lab_us-gaap_ScheduleOfHeldToMaturitySecuritiesTable" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OptionAdjustedSpread_401e4783-1d9f-4692-83b8-bede6f0f4bad_terseLabel_en-US" xlink:label="lab_rf_OptionAdjustedSpread" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option-Adjusted Spread</link:label>
    <link:label id="lab_rf_OptionAdjustedSpread_label_en-US" xlink:label="lab_rf_OptionAdjustedSpread" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option-Adjusted Spread</link:label>
    <link:label id="lab_rf_OptionAdjustedSpread_documentation_en-US" xlink:label="lab_rf_OptionAdjustedSpread" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option-Adjusted Spread</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OptionAdjustedSpread" xlink:href="rf-20220630.xsd#rf_OptionAdjustedSpread"/>
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    <link:label id="lab_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue_8c893f1d-acd0-44db-b1c4-ee77473d6213_terseLabel_en-US" xlink:label="lab_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in fair value, economic amortization associated with borrower repayments</link:label>
    <link:label id="lab_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue_label_en-US" xlink:label="lab_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Servicing Asset at Fair Value, Other Changes in Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue" xlink:to="lab_us-gaap_ServicingAssetAtFairValueOtherChangesInFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OtherConsumerExitPortfoliosMemberMember_8205dc40-1703-4542-a5a8-bd7df6d446de_terseLabel_en-US" xlink:label="lab_rf_OtherConsumerExitPortfoliosMemberMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OtherConsumerExitPortfoliosMember</link:label>
    <link:label id="lab_rf_OtherConsumerExitPortfoliosMemberMember_label_en-US" xlink:label="lab_rf_OtherConsumerExitPortfoliosMemberMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OtherConsumerExitPortfoliosMember [Member]</link:label>
    <link:label id="lab_rf_OtherConsumerExitPortfoliosMemberMember_documentation_en-US" xlink:label="lab_rf_OtherConsumerExitPortfoliosMemberMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OtherConsumerExitPortfoliosMember</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OtherConsumerExitPortfoliosMemberMember" xlink:href="rf-20220630.xsd#rf_OtherConsumerExitPortfoliosMemberMember"/>
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    <link:label id="lab_us-gaap_LoansReceivableFairValueDisclosure_557c94f7-3841-4356-995d-fd754deb5ad8_terseLabel_en-US" xlink:label="lab_us-gaap_LoansReceivableFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans (excluding leases), net of unearned income and allowance for loan losses</link:label>
    <link:label id="lab_us-gaap_LoansReceivableFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_LoansReceivableFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Receivable, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansReceivableFairValueDisclosure" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansReceivableFairValueDisclosure"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LoansReceivableFairValueDisclosure" xlink:to="lab_us-gaap_LoansReceivableFairValueDisclosure" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_HedgingRelationshipDomain_b67380fc-2f7f-4a8f-a92d-f6db3b342e29_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingRelationshipDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Relationship [Domain]</link:label>
    <link:label id="lab_us-gaap_HedgingRelationshipDomain_label_en-US" xlink:label="lab_us-gaap_HedgingRelationshipDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Relationship [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingRelationshipDomain" xlink:to="lab_us-gaap_HedgingRelationshipDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_a59fdad7-f48c-4a63-895e-6565406d5ac5_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule Of Cost And Estimated Fair Value Of Debt Securities Available For Sale And Debt Securities Held To Maturity By Contractual Maturity</link:label>
    <link:label id="lab_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_label_en-US" xlink:label="lab_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments Classified by Contractual Maturity Date [Table Text Block]</link:label>
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    <link:label id="lab_us-gaap_HedgingDesignationAxis_c0522fea-77e9-4d77-94eb-794884267c6e_terseLabel_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Axis]</link:label>
    <link:label id="lab_us-gaap_HedgingDesignationAxis_label_en-US" xlink:label="lab_us-gaap_HedgingDesignationAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Hedging Designation [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_HedgingDesignationAxis" xlink:to="lab_us-gaap_HedgingDesignationAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_PledgedAssetsLoansReceivableFRB_1eab89a8-7a1b-4df7-9d14-8a24ec44ed2f_terseLabel_en-US" xlink:label="lab_rf_PledgedAssetsLoansReceivableFRB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets, Loans Receivable, FRB</link:label>
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    <link:label id="lab_rf_PledgedAssetsLoansReceivableFRB_documentation_en-US" xlink:label="lab_rf_PledgedAssetsLoansReceivableFRB" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pledged Assets, Loans Receivable, FRB</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_PledgedAssetsLoansReceivableFRB" xlink:href="rf-20220630.xsd#rf_PledgedAssetsLoansReceivableFRB"/>
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    <link:label id="lab_us-gaap_LoansAndLeasesReceivableAllowance_df2d47ad-8175-4491-ad9f-f4fa5acdd5ba_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_LoansAndLeasesReceivableAllowance" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allowance for loan losses</link:label>
    <link:label id="lab_us-gaap_LoansAndLeasesReceivableAllowance_ea6ce406-da0b-4ded-901a-d2c59e5e3ff4_periodEndLabel_en-US" xlink:label="lab_us-gaap_LoansAndLeasesReceivableAllowance" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total allowance for loan losses</link:label>
    <link:label id="lab_us-gaap_LoansAndLeasesReceivableAllowance_6a3e914b-8c87-4153-9cba-106077feb751_periodStartLabel_en-US" xlink:label="lab_us-gaap_LoansAndLeasesReceivableAllowance" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allowance for loan losses, beginning of period</link:label>
    <link:label id="lab_us-gaap_LoansAndLeasesReceivableAllowance_label_en-US" xlink:label="lab_us-gaap_LoansAndLeasesReceivableAllowance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans and Leases Receivable, Allowance</link:label>
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    <link:label id="lab_dei_EntityFilerCategory_d168aa6e-debc-4b8f-b250-0eeabcbb20f2_terseLabel_en-US" xlink:label="lab_dei_EntityFilerCategory" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Filer Category</link:label>
    <link:label id="lab_dei_EntityFilerCategory_label_en-US" xlink:label="lab_dei_EntityFilerCategory" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Filer Category</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_CommercialMortgageLoansHeldForSaleMember" xlink:to="lab_rf_CommercialMortgageLoansHeldForSaleMember" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OtherConsumerFinancingReceivableMember_26f6ed38-76d9-4762-9b99-5edd19193957_terseLabel_en-US" xlink:label="lab_rf_OtherConsumerFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other consumer</link:label>
    <link:label id="lab_rf_OtherConsumerFinancingReceivableMember_label_en-US" xlink:label="lab_rf_OtherConsumerFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Consumer Financing Receivable [Member]</link:label>
    <link:label id="lab_rf_OtherConsumerFinancingReceivableMember_documentation_en-US" xlink:label="lab_rf_OtherConsumerFinancingReceivableMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Consumer Financing Receivable [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OtherConsumerFinancingReceivableMember" xlink:href="rf-20220630.xsd#rf_OtherConsumerFinancingReceivableMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_OtherConsumerFinancingReceivableMember" xlink:to="lab_rf_OtherConsumerFinancingReceivableMember" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_LoansIncludingFeesinInterestIncomeMember_ff0830e2-b2de-4eeb-9458-07f49a97085a_terseLabel_en-US" xlink:label="lab_rf_LoansIncludingFeesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Including Fees in Interest Income [Member]</link:label>
    <link:label id="lab_rf_LoansIncludingFeesinInterestIncomeMember_label_en-US" xlink:label="lab_rf_LoansIncludingFeesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Including Fees in Interest Income [Member]</link:label>
    <link:label id="lab_rf_LoansIncludingFeesinInterestIncomeMember_documentation_en-US" xlink:label="lab_rf_LoansIncludingFeesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Including Fees in Interest Income [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_LoansIncludingFeesinInterestIncomeMember" xlink:href="rf-20220630.xsd#rf_LoansIncludingFeesinInterestIncomeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_LoansIncludingFeesinInterestIncomeMember" xlink:to="lab_rf_LoansIncludingFeesinInterestIncomeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_SeriesDPreferredStockDividendScenario1Member_99b01036-3483-452b-8a28-47285d25e14e_terseLabel_en-US" xlink:label="lab_rf_SeriesDPreferredStockDividendScenario1Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series D Preferred Stock Dividend Scenario 1 [Member]</link:label>
    <link:label id="lab_rf_SeriesDPreferredStockDividendScenario1Member_label_en-US" xlink:label="lab_rf_SeriesDPreferredStockDividendScenario1Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series D Preferred Stock Dividend Scenario 1 [Member]</link:label>
    <link:label id="lab_rf_SeriesDPreferredStockDividendScenario1Member_documentation_en-US" xlink:label="lab_rf_SeriesDPreferredStockDividendScenario1Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Series D Preferred Stock Dividend Scenario 1 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_SeriesDPreferredStockDividendScenario1Member" xlink:href="rf-20220630.xsd#rf_SeriesDPreferredStockDividendScenario1Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_SeriesDPreferredStockDividendScenario1Member" xlink:to="lab_rf_SeriesDPreferredStockDividendScenario1Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_ebcb3efd-7e53-467f-bd98-63649971d725_terseLabel_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table]</link:label>
    <link:label id="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_label_en-US" xlink:label="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:to="lab_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_ConsumerBankMember_cc563c40-dc37-46c9-859a-404ae70698fc_terseLabel_en-US" xlink:label="lab_rf_ConsumerBankMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer Bank [Member]</link:label>
    <link:label id="lab_rf_ConsumerBankMember_label_en-US" xlink:label="lab_rf_ConsumerBankMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer Bank [Member]</link:label>
    <link:label id="lab_rf_ConsumerBankMember_documentation_en-US" xlink:label="lab_rf_ConsumerBankMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">A segment of Goodwill referred to as Consumer Bank [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_ConsumerBankMember" xlink:href="rf-20220630.xsd#rf_ConsumerBankMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_ConsumerBankMember" xlink:to="lab_rf_ConsumerBankMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_aa435c59-dba7-4ec8-adb4-2ef13385b92b_verboseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Financing Receivable [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_1a678574-0b3a-44ab-95b9-21e7c4ed9465_terseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Financing Receivable [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_label_en-US" xlink:label="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Financing Receivable [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:to="lab_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_DerivativeLiabilityNettingAdjustments_6a73b72e-5387-48c4-ac6e-429e95a0e0fd_terseLabel_en-US" xlink:label="lab_rf_DerivativeLiabilityNettingAdjustments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, netting adjustments</link:label>
    <link:label id="lab_rf_DerivativeLiabilityNettingAdjustments_label_en-US" xlink:label="lab_rf_DerivativeLiabilityNettingAdjustments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, netting adjustments</link:label>
    <link:label id="lab_rf_DerivativeLiabilityNettingAdjustments_documentation_en-US" xlink:label="lab_rf_DerivativeLiabilityNettingAdjustments" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, netting adjustments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_DerivativeLiabilityNettingAdjustments" xlink:href="rf-20220630.xsd#rf_DerivativeLiabilityNettingAdjustments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_DerivativeLiabilityNettingAdjustments" xlink:to="lab_rf_DerivativeLiabilityNettingAdjustments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_fcc7ddfe-89a5-4104-9839-600d8ab768f7_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Fair Value, Gross Asset</link:label>
    <link:label id="lab_us-gaap_DerivativeFairValueOfDerivativeAsset_label_en-US" xlink:label="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Subject to Master Netting Arrangement, before Offset</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:to="lab_us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ServicingAssetsAtFairValueTable_793eac41-97d8-475a-bc7a-e6239024120e_terseLabel_en-US" xlink:label="lab_us-gaap_ServicingAssetsAtFairValueTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Servicing Assets at Fair Value [Table]</link:label>
    <link:label id="lab_us-gaap_ServicingAssetsAtFairValueTable_label_en-US" xlink:label="lab_us-gaap_ServicingAssetsAtFairValueTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Servicing Assets at Fair Value [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ServicingAssetsAtFairValueTable" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ServicingAssetsAtFairValueTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ServicingAssetsAtFairValueTable" xlink:to="lab_us-gaap_ServicingAssetsAtFairValueTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProvisionForLoanAndLeaseLosses_ef8a9f90-e76f-4f84-863a-7cf398fecd8a_terseLabel_en-US" xlink:label="lab_us-gaap_ProvisionForLoanAndLeaseLosses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision (credit) for loan and lease losses</link:label>
    <link:label id="lab_us-gaap_ProvisionForLoanAndLeaseLosses_label_en-US" xlink:label="lab_us-gaap_ProvisionForLoanAndLeaseLosses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision for Loan and Lease Losses</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForLoanAndLeaseLosses" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForLoanAndLeaseLosses"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProvisionForLoanAndLeaseLosses" xlink:to="lab_us-gaap_ProvisionForLoanAndLeaseLosses" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressAddressLine1_7c4a7a29-a1f1-4d35-99fe-98ef846a1640_terseLabel_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
    <link:label id="lab_dei_EntityAddressAddressLine1_label_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressAddressLine1" xlink:to="lab_dei_EntityAddressAddressLine1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossTax_eefbb5d8-5481-4ae2-8722-39523f5d2ca1_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Tax</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossTax" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_TotalCommercialInvestorRealEstateConstructionMember_248b430d-f414-41c7-95c7-337c80776033_terseLabel_en-US" xlink:label="lab_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Investor Real Estate Construction [Member]</link:label>
    <link:label id="lab_rf_TotalCommercialInvestorRealEstateConstructionMember_label_en-US" xlink:label="lab_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Commercial Investor Real Estate Construction [Member]</link:label>
    <link:label id="lab_rf_TotalCommercialInvestorRealEstateConstructionMember_documentation_en-US" xlink:label="lab_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Commercial Investor Real Estate Construction [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:href="rf-20220630.xsd#rf_TotalCommercialInvestorRealEstateConstructionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:to="lab_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LongTermPurchaseCommitmentTable_6e9e85f1-5c67-4cc7-b2b2-dae816a71c40_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermPurchaseCommitmentTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Purchase Commitment [Table]</link:label>
    <link:label id="lab_us-gaap_LongTermPurchaseCommitmentTable_label_en-US" xlink:label="lab_us-gaap_LongTermPurchaseCommitmentTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-Term Purchase Commitment [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermPurchaseCommitmentTable" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermPurchaseCommitmentTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermPurchaseCommitmentTable" xlink:to="lab_us-gaap_LongTermPurchaseCommitmentTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CollateralAlreadyPostedAggregateFairValue_041cedb7-c739-420e-800c-5de1c4fec3c4_terseLabel_en-US" xlink:label="lab_us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Posted collateral related to derivative instruments with credit risk</link:label>
    <link:label id="lab_us-gaap_CollateralAlreadyPostedAggregateFairValue_label_en-US" xlink:label="lab_us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Collateral Already Posted, Aggregate Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralAlreadyPostedAggregateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:to="lab_us-gaap_CollateralAlreadyPostedAggregateFairValue" xlink:type="arc" order="1"/>
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    <link:label id="lab_us-gaap_PreferredStockLiquidationPreferenceValue_cf55ac21-51c9-4994-ab08-7a06a0732825_terseLabel_en-US" xlink:label="lab_us-gaap_PreferredStockLiquidationPreferenceValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preferred Stock, Liquidation Preference, Value</link:label>
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