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    <link:label id="lab_us-gaap_ServicingAssetAtFairValueAmount_9eb69999-3c6f-4e74-bee9-fc42df5f3173_terseLabel_en-US" xlink:label="lab_us-gaap_ServicingAssetAtFairValueAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential mortgage servicing rights at fair value</link:label>
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    <link:label id="lab_us-gaap_AwardTypeAxis_659d53dc-f210-4811-827a-cee62b81dff7_terseLabel_en-US" xlink:label="lab_us-gaap_AwardTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Type [Axis]</link:label>
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    <link:label id="lab_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup_f65ae1fe-fe0e-4b10-93a6-1e63e0ce4cd8_terseLabel_en-US" xlink:label="lab_us-gaap_LoansReceivableHeldForSaleNetNotPartOfDisposalGroup" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans held for sale</link:label>
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    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_86a03e13-6a60-4f53-ab29-c80557088eb6_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hierarchy and NAV [Domain]</link:label>
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    <link:label id="lab_us-gaap_Deposits_9a3460e4-f789-4a28-8f0b-65c13c2058eb_totalLabel_en-US" xlink:label="lab_us-gaap_Deposits" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total deposits</link:label>
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    <link:label id="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6a505d85-812f-4fc6-aa79-dfe208e5a6f8_terseLabel_en-US" xlink:label="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Income Tax Expense (Benefit), Continuing Operations [Abstract]</link:label>
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    <link:label id="lab_dei_DocumentType_e5aed94e-dc6c-4298-a3db-20b305f64707_terseLabel_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Type</link:label>
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    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_1d6252a0-5869-4418-ad0c-35cfa505c6b0_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Useful Life</link:label>
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    <link:label id="lab_rf_MortgageIncomeMember_documentation_en-US" xlink:label="lab_rf_MortgageIncomeMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mortgage Income [Member]</link:label>
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    <link:label id="lab_dei_EntityRegistrantName_label_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
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    <link:label id="lab_us-gaap_NonqualifiedPlanMember_38099627-1bf1-4ea6-86ac-7e36aac5ddab_terseLabel_en-US" xlink:label="lab_us-gaap_NonqualifiedPlanMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Nonqualified Plan [Member]</link:label>
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    <link:label id="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue_e772cd9e-4594-48dc-8926-ace95c0976c5_terseLabel_en-US" xlink:label="lab_us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Redeemed or Called During Period, Value</link:label>
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    <link:label id="lab_us-gaap_HomeEquityMember_4ed7cce5-0503-4aaf-9c55-b7d1abd89dfe_terseLabel_en-US" xlink:label="lab_us-gaap_HomeEquityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Home Equity Lines of Credit[Member]</link:label>
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    <link:label id="lab_us-gaap_HomeEquityMember_label_en-US" xlink:label="lab_us-gaap_HomeEquityMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Home Equity Line of Credit [Member]</link:label>
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    <link:label id="lab_rf_DefinedBenefitPlanAssetsFairValue_4c113a50-d8ae-4ca2-bfed-e3350719d544_terseLabel_en-US" xlink:label="lab_rf_DefinedBenefitPlanAssetsFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Defined Benefit Plan Assets, Fair Value</link:label>
    <link:label id="lab_rf_DefinedBenefitPlanAssetsFairValue_label_en-US" xlink:label="lab_rf_DefinedBenefitPlanAssetsFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Defined Benefit Plan Assets, Fair Value</link:label>
    <link:label id="lab_rf_DefinedBenefitPlanAssetsFairValue_documentation_en-US" xlink:label="lab_rf_DefinedBenefitPlanAssetsFairValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Defined Benefit Plan Assets, Fair Value</link:label>
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    <link:label id="lab_rf_TaxableDebtSecuritiesinInterestIncomeMember_190beda2-ecfa-4bc2-a9b5-b2f43a96d461_terseLabel_en-US" xlink:label="lab_rf_TaxableDebtSecuritiesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Taxable Debt Securities in Interest Income [Member]</link:label>
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    <link:label id="lab_rf_TaxableDebtSecuritiesinInterestIncomeMember_documentation_en-US" xlink:label="lab_rf_TaxableDebtSecuritiesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Taxable Debt Securities in Interest Income [Member]</link:label>
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    <link:label id="lab_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_6a250c6f-37ef-4aab-98b5-b75d848e06aa_terseLabel_en-US" xlink:label="lab_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Benefit Plans</link:label>
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    <link:label id="lab_us-gaap_InterestExpenseLongTermDebt_b5395151-95d9-4d8f-85b6-b133e5c9b413_terseLabel_en-US" xlink:label="lab_us-gaap_InterestExpenseLongTermDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term borrowings</link:label>
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    <link:label id="lab_us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet_d9771354-5b22-4a3d-a3c0-9ce94b6854e7_totalLabel_en-US" xlink:label="lab_us-gaap_LeveragedLeasesNetInvestmentInLeveragedLeasesDisclosureInvestmentInLeveragedLeasesNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total net investment</link:label>
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    <link:label id="lab_us-gaap_MutualFundMember_8520eb11-5953-48fc-b30c-079ebcf02a69_terseLabel_en-US" xlink:label="lab_us-gaap_MutualFundMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Mutual Funds [Member]</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_9e012e0c-cf93-4c16-876f-17dd38e046c8_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total equity</link:label>
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    <link:label id="lab_rf_FinancingReceivablePastDueBetween30And89Days_b4867c5d-e994-4409-8fb4-1f84e4f49f0e_terseLabel_en-US" xlink:label="lab_rf_FinancingReceivablePastDueBetween30And89Days" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, Past Due less than 90 days</link:label>
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    <link:label id="lab_dei_TradingSymbol_a28888b3-c6d2-4f1c-aa34-f45296603a7e_terseLabel_en-US" xlink:label="lab_dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Symbol</link:label>
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    <link:label id="lab_us-gaap_TransferOfLoansHeldForSaleToPortfolioLoans1_b9a8574c-7c14-42a5-85a9-e716a63637fe_terseLabel_en-US" xlink:label="lab_us-gaap_TransferOfLoansHeldForSaleToPortfolioLoans1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Transfer of Loans Held-for-sale to Portfolio Loans</link:label>
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    <link:label id="lab_rf_SalestypeDirectFinancingOperatingandLeveragedLeasesNetInvestmentAbstract_ff77ecfd-5bf5-4fb1-b8d4-60b8524e624a_terseLabel_en-US" xlink:label="lab_rf_SalestypeDirectFinancingOperatingandLeveragedLeasesNetInvestmentAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total</link:label>
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    <link:label id="lab_rf_LoansIncludingFeesinInterestIncomeMember_0ec66942-ab27-43b4-a426-f288134c8283_terseLabel_en-US" xlink:label="lab_rf_LoansIncludingFeesinInterestIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loans Including Fees in Interest Income [Member]</link:label>
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    <link:label id="lab_rf_SalestypeandDirectFinancingLeaseUnguaranteedResidualValueofLeasedAsset_documentation_en-US" xlink:label="lab_rf_SalestypeandDirectFinancingLeaseUnguaranteedResidualValueofLeasedAsset" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sales-type and Direct Financing Lease, Unguaranteed Residual Value of Leased Asset</link:label>
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    <link:label id="lab_us-gaap_InterestRateContractMember_d3fbd280-aec1-44e9-9d1e-869ec7a714a0_terseLabel_en-US" xlink:label="lab_us-gaap_InterestRateContractMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Rate Contract [Member]</link:label>
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    <link:label id="lab_us-gaap_NoninterestExpense_a76c1357-c5c5-4860-a81e-836b42dfe790_totalLabel_en-US" xlink:label="lab_us-gaap_NoninterestExpense" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total non-interest expense</link:label>
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    <link:label id="lab_us-gaap_NoninterestExpense_label_en-US" xlink:label="lab_us-gaap_NoninterestExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Noninterest Expense</link:label>
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    <link:label id="lab_rf_IndirectvehiclesandotherconsumerMember_40cac9f0-1d8e-4e9f-8d93-8e3d7d846452_terseLabel_en-US" xlink:label="lab_rf_IndirectvehiclesandotherconsumerMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indirect-vehicles and other consumer [Member]</link:label>
    <link:label id="lab_rf_IndirectvehiclesandotherconsumerMember_label_en-US" xlink:label="lab_rf_IndirectvehiclesandotherconsumerMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indirect-vehicles and other consumer [Member]</link:label>
    <link:label id="lab_rf_IndirectvehiclesandotherconsumerMember_documentation_en-US" xlink:label="lab_rf_IndirectvehiclesandotherconsumerMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indirect-vehicles and other consumer [Member]</link:label>
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    <link:label id="lab_us-gaap_SegmentContinuingOperationsMember_17a7e580-bbd8-4e13-bf73-954680105a97_terseLabel_en-US" xlink:label="lab_us-gaap_SegmentContinuingOperationsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Continuing Operations [Member]</link:label>
    <link:label id="lab_us-gaap_SegmentContinuingOperationsMember_label_en-US" xlink:label="lab_us-gaap_SegmentContinuingOperationsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Continuing Operations [Member]</link:label>
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    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities_a594f076-ca45-4623-bd78-1e254f19ce68_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other liabilities</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities"/>
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    <link:label id="lab_us-gaap_TierOneLeverageCapitalAbstract_539c7938-3043-4bb3-a692-2e7b62af0489_terseLabel_en-US" xlink:label="lab_us-gaap_TierOneLeverageCapitalAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leverage Capital</link:label>
    <link:label id="lab_us-gaap_TierOneLeverageCapitalAbstract_label_en-US" xlink:label="lab_us-gaap_TierOneLeverageCapitalAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Banking Regulation, Tier 1 Leverage Capital [Abstract]</link:label>
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    <link:label id="lab_srt_WeightedAverageMember_0bc174cc-819e-4cf2-8ada-ce5f9d46c728_terseLabel_en-US" xlink:label="lab_srt_WeightedAverageMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average [Member]</link:label>
    <link:label id="lab_srt_WeightedAverageMember_label_en-US" xlink:label="lab_srt_WeightedAverageMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average [Member]</link:label>
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    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_c739dac1-60e2-4dc9-993f-f08231b6aa97_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Asset, Expected Amortization, Year One</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
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    <link:label id="lab_us-gaap_DefinedBenefitPlanBenefitObligation_a4ae27d8-bf41-4bfd-b199-2dffab1c872c_periodStartLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanBenefitObligation" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Projected Benefit Obligation, Beginning of Period</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedBenefitPlanBenefitObligation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DefinedBenefitPlanBenefitObligation" xlink:to="lab_us-gaap_DefinedBenefitPlanBenefitObligation" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConsumerPortfolioSegmentMember_18c6305d-01c3-4fc3-b8fb-ba398c99e193_terseLabel_en-US" xlink:label="lab_us-gaap_ConsumerPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer Portfolio Segment [Member]</link:label>
    <link:label id="lab_us-gaap_ConsumerPortfolioSegmentMember_label_en-US" xlink:label="lab_us-gaap_ConsumerPortfolioSegmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consumer Portfolio Segment [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsumerPortfolioSegmentMember" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConsumerPortfolioSegmentMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsumerPortfolioSegmentMember" xlink:to="lab_us-gaap_ConsumerPortfolioSegmentMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_732f7b61-efdf-428e-ac71-8aa55c10f496_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
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    <link:label id="lab_rf_FICOScoresAbove720Member_c2732f3b-6a9f-43ac-8bd8-9a6d0a542a09_terseLabel_en-US" xlink:label="lab_rf_FICOScoresAbove720Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICO Scores, Above 720 [Member]</link:label>
    <link:label id="lab_rf_FICOScoresAbove720Member_label_en-US" xlink:label="lab_rf_FICOScoresAbove720Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICO Scores, Above 720 [Member]</link:label>
    <link:label id="lab_rf_FICOScoresAbove720Member_documentation_en-US" xlink:label="lab_rf_FICOScoresAbove720Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">FICO Scores, Above 720 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_FICOScoresAbove720Member" xlink:href="rf-20221231.xsd#rf_FICOScoresAbove720Member"/>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_6188235d-78f8-44b2-907f-beed9998cb0b_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, within One Year, Fair Value</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
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    <link:label id="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Stockholders' Equity [Roll Forward]</link:label>
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    <link:label id="lab_us-gaap_DividendIncomeOperating_8499f9d3-2eb9-4798-ad63-7cc4c7a5eae5_terseLabel_en-US" xlink:label="lab_us-gaap_DividendIncomeOperating" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Dividends Paid to Parent Company by Consolidated Subsidiaries</link:label>
    <link:label id="lab_us-gaap_DividendIncomeOperating_label_en-US" xlink:label="lab_us-gaap_DividendIncomeOperating" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividend Income, Operating</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendIncomeOperating" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendIncomeOperating"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DividendIncomeOperating" xlink:to="lab_us-gaap_DividendIncomeOperating" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OtherMiscellaneousIncome_9056cb0e-0082-498f-91ec-cf3477282f1d_terseLabel_en-US" xlink:label="lab_rf_OtherMiscellaneousIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Miscellaneous Income</link:label>
    <link:label id="lab_rf_OtherMiscellaneousIncome_label_en-US" xlink:label="lab_rf_OtherMiscellaneousIncome" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Miscellaneous Income</link:label>
    <link:label id="lab_rf_OtherMiscellaneousIncome_documentation_en-US" xlink:label="lab_rf_OtherMiscellaneousIncome" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other miscellaneous income</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OtherMiscellaneousIncome" xlink:href="rf-20221231.xsd#rf_OtherMiscellaneousIncome"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_OtherMiscellaneousIncome" xlink:to="lab_rf_OtherMiscellaneousIncome" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward_df0e5355-7aa1-49e8-88fd-7144e46f4d10_terseLabel_en-US" xlink:label="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reserve For Unfunded Credit Commitments [Roll Forward]</link:label>
    <link:label id="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward_label_en-US" xlink:label="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reserve For Unfunded Credit Commitments [Roll Forward]</link:label>
    <link:label id="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward_documentation_en-US" xlink:label="lab_rf_ReserveForUnfundedCreditCommitmentsRollForward" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reserve For Unfunded Credit Commitments [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_ReserveForUnfundedCreditCommitmentsRollForward" xlink:href="rf-20221231.xsd#rf_ReserveForUnfundedCreditCommitmentsRollForward"/>
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    <link:label id="lab_srt_StatementScenarioAxis_6259f656-f51c-4dc5-91cb-52d740b39218_terseLabel_en-US" xlink:label="lab_srt_StatementScenarioAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Scenario [Axis]</link:label>
    <link:label id="lab_srt_StatementScenarioAxis_label_en-US" xlink:label="lab_srt_StatementScenarioAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Scenario [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_StatementScenarioAxis" xlink:to="lab_srt_StatementScenarioAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_a4048bb9-2482-478f-8d2e-e27cbc5e1a63_terseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Fair Value Disclosure</link:label>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure" xlink:to="lab_us-gaap_AssetsFairValueDisclosure" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LesseeOperatingLeasesTextBlock_16b4e24f-7573-4142-a975-86405b794d39_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeasesTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lessee, Operating Leases [Text Block]</link:label>
    <link:label id="lab_us-gaap_LesseeOperatingLeasesTextBlock_label_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeasesTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lessee, Operating Leases [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LesseeOperatingLeasesTextBlock" xlink:to="lab_us-gaap_LesseeOperatingLeasesTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OCIBeforeReclassificationsTaxAttributableToParent_32c4c189-5e33-40f5-9c3d-00b1a8e21a0b_terseLabel_en-US" xlink:label="lab_rf_OCIBeforeReclassificationsTaxAttributableToParent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OCI, before reclassifications, tax, attributable to parent</link:label>
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    <link:label id="lab_rf_OCIBeforeReclassificationsTaxAttributableToParent_documentation_en-US" xlink:label="lab_rf_OCIBeforeReclassificationsTaxAttributableToParent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount of tax related to OCI before reclassification adjustments of other comprehensive income (loss) attributable to parent.</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_OCIBeforeReclassificationsTaxAttributableToParent" xlink:to="lab_rf_OCIBeforeReclassificationsTaxAttributableToParent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USStatesAndPoliticalSubdivisionsMember_a7983365-a4d3-4474-adfc-10c67065484d_terseLabel_en-US" xlink:label="lab_us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US States and Political Subdivisions Debt Securities</link:label>
    <link:label id="lab_us-gaap_USStatesAndPoliticalSubdivisionsMember_label_en-US" xlink:label="lab_us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US States and Political Subdivisions Debt Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:to="lab_us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtAndCapitalLeaseObligations_cc4a92a1-e44f-4946-bba9-c429cb64ba17_totalLabel_en-US" xlink:label="lab_us-gaap_DebtAndCapitalLeaseObligations" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total borrowed funds</link:label>
    <link:label id="lab_us-gaap_DebtAndCapitalLeaseObligations_label_en-US" xlink:label="lab_us-gaap_DebtAndCapitalLeaseObligations" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt and Lease Obligation</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtAndCapitalLeaseObligations" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtAndCapitalLeaseObligations"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtAndCapitalLeaseObligations" xlink:to="lab_us-gaap_DebtAndCapitalLeaseObligations" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_CorporateBankMember_569d295b-b1db-449b-bdfb-50da787ce139_terseLabel_en-US" xlink:label="lab_rf_CorporateBankMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Bank [Member]</link:label>
    <link:label id="lab_rf_CorporateBankMember_label_en-US" xlink:label="lab_rf_CorporateBankMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Bank [Member]</link:label>
    <link:label id="lab_rf_CorporateBankMember_documentation_en-US" xlink:label="lab_rf_CorporateBankMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">A segment of Goodwill referred to as the Corporate Bank [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_CorporateBankMember" xlink:href="rf-20221231.xsd#rf_CorporateBankMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_CorporateBankMember" xlink:to="lab_rf_CorporateBankMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_4757d96b-22c9-477b-b43d-2e502fff6684_terseLabel_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allocated Share-based Compensation Expense, Net of Tax</link:label>
    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_label_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-Based Payment Arrangement, Expense, after Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:to="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost_fc8ccb23-0ee6-4d02-9e8b-5c0365e1ccc2_terseLabel_en-US" xlink:label="lab_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Closed Portfolio and Beneficial Interest, Last-of-Layer, Amortized Cost</link:label>
    <link:label id="lab_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost_label_en-US" xlink:label="lab_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Closed Portfolio and Beneficial Interest, Last-of-Layer, Amortized Cost</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost" xlink:to="lab_us-gaap_ClosedPortfolioAndBeneficialInterestLastOfLayerAmortizedCost" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_NetOperatingLossesFederalDateRange1Member_6506bcf8-2979-4295-adea-98bd9b5dc396_terseLabel_en-US" xlink:label="lab_rf_NetOperatingLossesFederalDateRange1Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Operating Losses Federal Date Range 1</link:label>
    <link:label id="lab_rf_NetOperatingLossesFederalDateRange1Member_label_en-US" xlink:label="lab_rf_NetOperatingLossesFederalDateRange1Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Operating Losses Federal Date Range 1 [Member]</link:label>
    <link:label id="lab_rf_NetOperatingLossesFederalDateRange1Member_documentation_en-US" xlink:label="lab_rf_NetOperatingLossesFederalDateRange1Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Operating Losses Federal Date Range 1</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_NetOperatingLossesFederalDateRange1Member" xlink:href="rf-20221231.xsd#rf_NetOperatingLossesFederalDateRange1Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_NetOperatingLossesFederalDateRange1Member" xlink:to="lab_rf_NetOperatingLossesFederalDateRange1Member" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OptionAdjustedSpreadBasisPoints_f4ad902b-533a-4df5-862a-a2c408932cef_terseLabel_en-US" xlink:label="lab_rf_OptionAdjustedSpreadBasisPoints" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option-adjusted spread (basis points)</link:label>
    <link:label id="lab_rf_OptionAdjustedSpreadBasisPoints_label_en-US" xlink:label="lab_rf_OptionAdjustedSpreadBasisPoints" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option Adjusted Spread Basis Points</link:label>
    <link:label id="lab_rf_OptionAdjustedSpreadBasisPoints_documentation_en-US" xlink:label="lab_rf_OptionAdjustedSpreadBasisPoints" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Option-adjusted spread (basis points)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OptionAdjustedSpreadBasisPoints" xlink:href="rf-20221231.xsd#rf_OptionAdjustedSpreadBasisPoints"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_OptionAdjustedSpreadBasisPoints" xlink:to="lab_rf_OptionAdjustedSpreadBasisPoints" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_IntangibleAssetsLineItems_6932ea46-2c68-4f3d-a654-64abf54f0f27_terseLabel_en-US" xlink:label="lab_rf_IntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets [Line Items]</link:label>
    <link:label id="lab_rf_IntangibleAssetsLineItems_label_en-US" xlink:label="lab_rf_IntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets [Line Items]</link:label>
    <link:label id="lab_rf_IntangibleAssetsLineItems_documentation_en-US" xlink:label="lab_rf_IntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_IntangibleAssetsLineItems" xlink:href="rf-20221231.xsd#rf_IntangibleAssetsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_IntangibleAssetsLineItems" xlink:to="lab_rf_IntangibleAssetsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_30195c6d-0234-403d-8129-67f5ca6ffafc_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_c39f50a5-b4e3-47ea-8169-9d1f0e9f88b8_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and intangibles</link:label>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Goodwill and Intangible Assets</link:label>
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    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_899fa3ca-8f45-4346-99a5-0ea8c9cd689f_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
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    <link:label id="lab_us-gaap_OtherInterestAndDividendIncome_152efcc2-39db-44cf-a08b-e2c1df616c60_terseLabel_en-US" xlink:label="lab_us-gaap_OtherInterestAndDividendIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other earning assets</link:label>
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    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_af63fae5-4a4e-46f1-be04-0eef3d3ad8d3_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash from operating activities</link:label>
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    <link:label id="lab_rf_CommercialinvestorrealestatemortgageMember_4b5be73b-a3bf-4c36-b732-7c9f6a5429dd_terseLabel_en-US" xlink:label="lab_rf_CommercialinvestorrealestatemortgageMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial investor real estate mortgage [Member]</link:label>
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    <link:label id="lab_us-gaap_FinancialInstrumentAxis_0861f3ea-35aa-44b6-a0e3-ed683b932f41_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
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    <link:label id="lab_us-gaap_MarketingExpense_dfb1d60d-d001-4573-b2e7-16e719c356ca_terseLabel_en-US" xlink:label="lab_us-gaap_MarketingExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Marketing Expense</link:label>
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    <link:label id="lab_rf_ResidentialAgencyMember_8d442720-8c83-4c1d-b0c7-2a7dc1ea253a_terseLabel_en-US" xlink:label="lab_rf_ResidentialAgencyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential Agency [Member]</link:label>
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    <link:label id="lab_rf_ResidentialAgencyMember_documentation_en-US" xlink:label="lab_rf_ResidentialAgencyMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Residential Agency [Member]</link:label>
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    <link:label id="lab_us-gaap_SpecialMentionMember_491e8fb2-0ce1-46b3-9af4-eaf045ea6d29_terseLabel_en-US" xlink:label="lab_us-gaap_SpecialMentionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Special Mention [Member]</link:label>
    <link:label id="lab_us-gaap_SpecialMentionMember_label_en-US" xlink:label="lab_us-gaap_SpecialMentionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Special Mention [Member]</link:label>
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    <link:label id="lab_rf_PurchasedCreditCardRelationshipsMember_5f6ec7d9-ffd5-4824-865d-0b049b15b56e_terseLabel_en-US" xlink:label="lab_rf_PurchasedCreditCardRelationshipsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchased Credit Card Relationships [Member]</link:label>
    <link:label id="lab_rf_PurchasedCreditCardRelationshipsMember_label_en-US" xlink:label="lab_rf_PurchasedCreditCardRelationshipsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchased Credit Card Relationships [Member]</link:label>
    <link:label id="lab_rf_PurchasedCreditCardRelationshipsMember_documentation_en-US" xlink:label="lab_rf_PurchasedCreditCardRelationshipsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchased Credit Card Relationships [Member]</link:label>
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    <link:label id="lab_us-gaap_TreasuryStockMember_bbd360ed-8f33-483e-b207-91993515a341_terseLabel_en-US" xlink:label="lab_us-gaap_TreasuryStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Treasury Stock, At Cost [Member]</link:label>
    <link:label id="lab_us-gaap_TreasuryStockMember_label_en-US" xlink:label="lab_us-gaap_TreasuryStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Treasury Stock [Member]</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquity_2c80a33c-979b-49be-a736-7423f0bf87da_terseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total shareholders&#8217; equity</link:label>
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    <link:label id="lab_us-gaap_StockholdersEquity_d8df7da7-30a3-4ffc-9729-90a0719e9617_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total shareholders&#8217; equity</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity" xlink:to="lab_us-gaap_StockholdersEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_OutsideFeesAndServicesExpenses_a1c80434-d043-40e2-b1b5-404d91ba6819_terseLabel_en-US" xlink:label="lab_rf_OutsideFeesAndServicesExpenses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outside Services</link:label>
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    <link:label id="lab_rf_OutsideFeesAndServicesExpenses_documentation_en-US" xlink:label="lab_rf_OutsideFeesAndServicesExpenses" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outside Fees And Services Expenses</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_OutsideFeesAndServicesExpenses" xlink:href="rf-20221231.xsd#rf_OutsideFeesAndServicesExpenses"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_rf_OutsideFeesAndServicesExpenses" xlink:to="lab_rf_OutsideFeesAndServicesExpenses" xlink:type="arc" order="1"/>
    <link:label id="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff_26cf0f89-cb49-4f91-93da-08d1b47c4e5b_terseLabel_en-US" xlink:label="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Days for certain equipment finance loans to be evaluated as potential charge off</link:label>
    <link:label id="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff_label_en-US" xlink:label="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Days for certain equipment finance loans to be evaluated as potential charge off</link:label>
    <link:label id="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff_documentation_en-US" xlink:label="lab_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Days for certain equipment finance loans to be evaluated as potential charge off</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff" xlink:href="rf-20221231.xsd#rf_DaysForCertainEquipmentFinanceLoansToBeEvaluatedAsPotentialChargeOff"/>
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    <link:label id="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold_252924d4-412f-4a35-a653-775f6487d328_terseLabel_en-US" xlink:label="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receiable, Allowance for Credit loss, writeoff on loans sold</link:label>
    <link:label id="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold_label_en-US" xlink:label="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receiable, Allowance for Credit loss, writeoff on loans sold</link:label>
    <link:label id="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold_documentation_en-US" xlink:label="lab_rf_FinancingReceiableAllowanceForCreditLossWriteoffOnLoansSold" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receiable, Allowance for Credit loss, writeoff on loans sold</link:label>
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    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_25226d5d-ae59-454b-8a13-2af390828103_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted-Average Grant Date Fair Value, Forfeited</link:label>
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    <link:label id="lab_us-gaap_TierOneLeverageCapital_f50784a8-6c21-4058-9cd9-4c6dff09b34f_terseLabel_en-US" xlink:label="lab_us-gaap_TierOneLeverageCapital" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leverage, Amount</link:label>
    <link:label id="lab_us-gaap_TierOneLeverageCapital_label_en-US" xlink:label="lab_us-gaap_TierOneLeverageCapital" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Banking Regulation, Tier 1 Leverage Capital, Actual</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TierOneLeverageCapital" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapital"/>
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    <link:label id="lab_us-gaap_FinancingReceivablePortfolioSegmentDomain_4d9a6707-7319-4b38-986f-14d8b89c6f1c_terseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable Portfolio Segment [Domain]</link:label>
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    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain"/>
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    <link:label id="lab_rf_BankMember_937cf07e-2e25-47c4-bbcd-207f04721986_terseLabel_en-US" xlink:label="lab_rf_BankMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank [Member]</link:label>
    <link:label id="lab_rf_BankMember_label_en-US" xlink:label="lab_rf_BankMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank [Member]</link:label>
    <link:label id="lab_rf_BankMember_documentation_en-US" xlink:label="lab_rf_BankMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_rf_BankMember" xlink:href="rf-20221231.xsd#rf_BankMember"/>
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    <link:label id="lab_us-gaap_DeferredTaxAssetsOther_99dc8fec-8a1a-4cb9-b36e-4fa394504283_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
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    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_a12663e8-6869-4109-a84f-ff10d25a4485_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Accumulated Amortization</link:label>
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    <link:label id="lab_us-gaap_BankingRegulationCapitalConservationBufferCapitalConservedMinimum_9b4551ba-229a-4b06-9693-65d7df8afe64_terseLabel_en-US" xlink:label="lab_us-gaap_BankingRegulationCapitalConservationBufferCapitalConservedMinimum" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Banking Regulation, Capital Conservation Buffer, Capital Conserved, Minimum</link:label>
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    <link:label id="lab_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_de21d2cf-c0bf-49e2-a71b-bde4ee42e1e0_terseLabel_en-US" xlink:label="lab_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing Receivable, Allowance for Credit Losses [Line Items]</link:label>
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    <link:label id="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_e6ba711f-e5d1-4dc8-8dee-44c90bbd9900_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued expenses</link:label>
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    <link:label id="lab_rf_AccountReceivableChangeinMethodCreditLoss_1b197e68-8c0f-40c1-bb4c-0a27dbdb916b_terseLabel_en-US" xlink:label="lab_rf_AccountReceivableChangeinMethodCreditLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cumulative change in accounting guidance</link:label>
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    <link:label id="lab_rf_TotalCommercialInvestorRealEstateConstructionMember_documentation_en-US" xlink:label="lab_rf_TotalCommercialInvestorRealEstateConstructionMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Commercial Investor Real Estate Construction [Member]</link:label>
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    <link:label id="lab_us-gaap_LongTermPurchaseCommitmentTable_675e6e4e-a4d1-4da2-a7b6-bb198cb2f5b1_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermPurchaseCommitmentTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Purchase Commitment [Table]</link:label>
    <link:label id="lab_us-gaap_LongTermPurchaseCommitmentTable_label_en-US" xlink:label="lab_us-gaap_LongTermPurchaseCommitmentTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-Term Purchase Commitment [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermPurchaseCommitmentTable" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermPurchaseCommitmentTable"/>
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    <link:label id="lab_rf_ProvisionForDeferredIncomeTaxes_28f0ce47-f690-4bf0-89cd-53efa20e777f_negatedLabel_en-US" xlink:label="lab_rf_ProvisionForDeferredIncomeTaxes" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision for deferred income taxes</link:label>
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    <link:label id="lab_rf_ProvisionForDeferredIncomeTaxes_documentation_en-US" xlink:label="lab_rf_ProvisionForDeferredIncomeTaxes" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision for deferred income taxes</link:label>
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    <link:label id="lab_us-gaap_RealEstateFundsMember_aabfa365-405a-4887-92c8-9c3c5325d2c6_terseLabel_en-US" xlink:label="lab_us-gaap_RealEstateFundsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Real Estate Funds [Member]</link:label>
    <link:label id="lab_us-gaap_RealEstateFundsMember_label_en-US" xlink:label="lab_us-gaap_RealEstateFundsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Real Estate Funds [Member]</link:label>
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    <link:label id="lab_us-gaap_TimeDepositMaturitiesTableTextBlock_253ba2b2-6e47-4942-8349-deafac25178b_terseLabel_en-US" xlink:label="lab_us-gaap_TimeDepositMaturitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule Of Aggregate Amount Of Maturities Of All Time Deposits</link:label>
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    <link:label id="lab_rf_SalestypeDirectFinancingOperatingandLeveragedLeasesNetInvestment_ab93a185-02b7-4259-8016-bb5f8373632f_totalLabel_en-US" xlink:label="lab_rf_SalestypeDirectFinancingOperatingandLeveragedLeasesNetInvestment" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total net investment</link:label>
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    <link:label id="lab_srt_ProductOrServiceAxis_6038888e-1062-473a-b6f8-300449596043_terseLabel_en-US" xlink:label="lab_srt_ProductOrServiceAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Axis]</link:label>
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    <link:label id="lab_us-gaap_ClassOfStockDomain_ba5d6fd6-33ad-4cd8-9a6c-e3ce694a8903_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfStockDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Stock [Domain]</link:label>
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    <link:label id="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_10e42d7d-4bc2-40f0-8cc0-b3a73efddc79_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expected return on plan assets</link:label>
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    <link:label id="lab_rf_ProvisionForUnfundedCreditCommitments_bbb704c7-5d54-410d-a187-00d968a2f667_verboseLabel_en-US" xlink:label="lab_rf_ProvisionForUnfundedCreditCommitments" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision (credit) for unfunded credit losses</link:label>
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    <link:label id="lab_us-gaap_InterestExpense_ee63ba81-199f-4617-9aac-780d87bbdddf_totalLabel_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total interest expense</link:label>
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    <link:label id="lab_us-gaap_InsuranceRecoveries_ed836fdf-d5ef-4e5f-901e-c2cc9c28388c_terseLabel_en-US" xlink:label="lab_us-gaap_InsuranceRecoveries" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Insurance proceeds</link:label>
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