XML 86 R66.htm IDEA: XBRL DOCUMENT v3.24.0.1
Income taxes - Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Thousands
Dec. 31, 2023
Dec. 31, 2022
Deferred tax assets:    
Net operating loss carryforwards $ 751,273 $ 900,200
Research tax credits 570,061 473,248
Reserves, accruals, and other 26,855 31,502
Lease obligation 44,676 56,185
Share-based compensation 30,146 40,976
Research capitalization and amortization 411,113 208,373
Total deferred tax assets 1,834,124 1,710,484
Less: valuation allowance (1,821,027) (1,660,609)
Deferred tax assets, net of valuation allowance 13,097 49,875
Deferred tax liabilities:    
Depreciation and amortization (7,467) (44,790)
Prepaid expenses (2,682) (4,190)
Total deferred tax liabilities (10,149) (48,980)
Deferred tax assets $ 2,948 $ 895