Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement (Form S-8 No. 333-205441) pertaining to the 2007 Stock Plan, 2015 Equity Incentive Plan and 2015 Employee Stock Purchase Plan of Natera, I nc. of our report dated March 2 3, 2016, with respect to the consolidated financial statements of Natera, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2015, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Redwood City, California

March 2 3, 2016