v3.6.0.2

Quarterly Financial Data (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating results: |  |  |  |  |  |  |  |  |  |  |
Total revenues | $ 49,299 | $ 53,889 | $ 51,984 | $ 61,902 | $ 52,912 | $ 44,921 | $ 45,087 | $ 47,435 | $ 217,074 | $ 190,355 | $ 159,289
Cost of product, licensing and other revenues | 38,000 | 34,261 | 30,973 | 32,340 | 31,814 | 30,456 | 25,732 | 24,843 | 135,574 | 112,845 | 78,396
Gross profit | 11,299 | 19,628 | 21,011 | 29,562 | 21,098 | 14,465 | 19,355 | 22,592 |  |  |
Other costs and expenses | 49,012 | 46,283 | 43,526 | 39,167 | 38,446 | 35,206 | 34,827 | 28,869 |  |  |
Interest expense and other (expense) income, net | (155) | 741 | (641) | 920 | (5,612) | 3,111 | (4,209) | (3,727) |  |  |
Income tax expense | (39) | (103) |  |  |  |  |  |  | (142) |  |
Net loss | $ (37,907) | $ (26,017) | $ (23,156) | $ (8,685) | $ (22,960) | $ (17,630) | $ (19,681) | $ (10,004) | $ (95,765) | $ (70,275) | $ (5,152)
Per share data: |  |  |  |  |  |  |  |  |  |  |
Basic and diluted net loss per share (in dollars per share) | $ (0.72) | $ (0.50) | $ (0.46) | $ (0.17) | $ (0.47) | $ (0.39) | $ (3.58) | $ (1.89) | $ (1.86) | $ (2.68) | $ (1.07)

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