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Condensed Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Common stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2019 | $ 8 | $ 976,955 | $ 919 | $ (699,171) | $ 278,711
Balance (in shares) at Dec. 31, 2019 | 78,005 |  |  |  |
Issuance of common stock upon exercise of stock options |  | 15,782 |  |  | 15,782
Issuance of common stock upon exercise of stock options (in shares) | 1,534 |  |  |  |
Issuance of common stock under employee stock purchase plan |  | 3,062 |  |  | 3,062
Issuance of common stock under employee stock purchase plan (in shares) | 97 |  |  |  |
Equity component of Convertible Notes, net |  | 82,873 |  |  | 82,873
Issuance of common stock for public offering, net | $ 1 | 270,649 |  |  | 270,650
Issuance of common stock for public offering, net (in shares) | 4,792 |  |  |  |
Vesting of restricted stock units (in shares) | 853 |  |  |  |
Stock based compensation |  | 34,406 |  |  | 34,406
Unrealized (loss) gain on available-for-sale securities |  |  | 4,251 |  | 4,251
Cumulative-effect adjustment upon adoption |  |  |  | (404) | (404)
Net loss |  |  |  | (153,331) | (153,331)
Balance at Sep. 30, 2020 | $ 9 | 1,383,727 | 5,170 | (852,906) | 536,000
Balance (in shares) at Sep. 30, 2020 | 85,281 |  |  |  |
Balance at Jun. 30, 2020 | $ 8 | 1,093,072 | 5,770 | (794,583) | 304,267
Balance (in shares) at Jun. 30, 2020 | 79,717 |  |  |  |
Issuance of common stock upon exercise of stock options |  | 4,974 |  |  | 4,974
Issuance of common stock upon exercise of stock options (in shares) | 498 |  |  |  |
Issuance of common stock for public offering, net | $ 1 | 270,649 |  |  | 270,650
Issuance of common stock for public offering, net (in shares) | 4,792 |  |  |  |
Vesting of restricted stock units (in shares) | 274 |  |  |  |
Stock based compensation |  | 15,032 |  |  | 15,032
Unrealized (loss) gain on available-for-sale securities |  |  | (600) |  | (600)
Net loss |  |  |  | (58,323) | (58,323)
Balance at Sep. 30, 2020 | $ 9 | 1,383,727 | 5,170 | (852,906) | 536,000
Balance (in shares) at Sep. 30, 2020 | 85,281 |  |  |  |
Balance at Dec. 31, 2020 | $ 9 | 1,411,286 | 4,259 | (929,318) | $ 486,236
Balance (in shares) at Dec. 31, 2020 | 86,223 |  |  |  | 86,223
Issuance of common stock upon exercise of stock options |  | 10,774 |  |  | $ 10,774
Issuance of common stock upon exercise of stock options (in shares) | 1,051 |  |  |  |
Issuance of common stock under employee stock purchase plan |  | 6,085 |  |  | 6,085
Issuance of common stock under employee stock purchase plan (in shares) | 106 |  |  |  |
Issuance of common stock for public offering, net | $ 1 | 550,821 |  |  | 550,822
Issuance of common stock for public offering, net (in shares) | 5,175 |  |  |  |
Issuance of common stock for IPR&D acquisition |  | 30,901 |  |  | 30,901
Issuance of common stock for IPR&D acquisition (in shares) | 276 |  |  |  |
Vesting of restricted stock units (in shares) | 1,707 |  |  |  |
Stock based compensation |  | 84,797 |  |  | 84,797
Unrealized (loss) gain on available-for-sale securities |  |  | (2,768) |  | (2,768)
Cumulative-effect adjustment upon adoption |  | (82,876) |  | 6,198 | (76,678)
Net loss |  |  |  | (331,152) | (331,152)
Balance at Sep. 30, 2021 | $ 10 | 2,011,788 | 1,491 | (1,254,272) | $ 759,017
Balance (in shares) at Sep. 30, 2021 | 94,538 |  |  |  | 94,538
Balance at Jun. 30, 2021 | $ 9 | 1,399,659 | 2,441 | (1,102,999) | $ 299,110
Balance (in shares) at Jun. 30, 2021 | 88,498 |  |  |  |
Issuance of common stock upon exercise of stock options |  | 3,945 |  |  | 3,945
Issuance of common stock upon exercise of stock options (in shares) | 268 |  |  |  |
Issuance of common stock for public offering, net | $ 1 | 550,821 |  |  | 550,822
Issuance of common stock for public offering, net (in shares) | 5,176 |  |  |  |
Issuance of common stock for IPR&D acquisition |  | 30,901 |  |  | 30,901
Issuance of common stock for IPR&D acquisition (in shares) | 276 |  |  |  |
Vesting of restricted stock units |  | 3 |  |  | 3
Vesting of restricted stock units (in shares) | 320 |  |  |  |
Stock based compensation |  | 26,459 |  |  | 26,459
Unrealized (loss) gain on available-for-sale securities |  |  | (950) |  | (950)
Net loss |  |  |  | (151,273) | (151,273)
Balance at Sep. 30, 2021 | $ 10 | $ 2,011,788 | $ 1,491 | $ (1,254,272) | $ 759,017
Balance (in shares) at Sep. 30, 2021 | 94,538 |  |  |  | 94,538

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