-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 AaKYr0V5sWSDIWYAOZvTLL4LNh3cHcGgMMCoA7SOJkI8Bvh3Xz5wydb5EP9zxiHw
 C4eFiBZHLjYcMKqwQoWmKg==

<SEC-DOCUMENT>0000950117-06-003285.txt : 20060802
<SEC-HEADER>0000950117-06-003285.hdr.sgml : 20060802
<ACCEPTANCE-DATETIME>20060801174634
ACCESSION NUMBER:		0000950117-06-003285
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20060731
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20060802
DATE AS OF CHANGE:		20060801

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			QUEST DIAGNOSTICS INC
		CENTRAL INDEX KEY:			0001022079
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				161387862
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-12215
		FILM NUMBER:		06995499

	BUSINESS ADDRESS:	
		STREET 1:		ONE MALCOLM AVE
		CITY:			TETERBORO
		STATE:			NJ
		ZIP:			07608
		BUSINESS PHONE:		2013935000

	MAIL ADDRESS:	
		STREET 1:		ONE MALCOLM AVE
		CITY:			TETERBORO
		STATE:			NJ
		ZIP:			07601

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CORNING CLINICAL LABORATORIES INC
		DATE OF NAME CHANGE:	19960903
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>a42473.htm
<DESCRIPTION>QUEST DIAGNOSTICS INCORPORATED
<TEXT>
<HTML>
<HEAD>
<TITLE> </TITLE>
</HEAD>
<BODY bgcolor="#ffffff" style='font-family:"Times New Roman"'>




<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font SIZE=5>SECURITIES AND EXCHANGE COMMISSION</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font SIZE=2>WASHINGTON, DC 20549</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;border-bottom:solid black 1px'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font SIZE=5>FORM 8-K</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>THE SECURITIES EXCHANGE ACT OF 1934</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>Date of Report (Date of Earliest Event Reported): July 31, 2006</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>Commission file number 001-12215</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=5>Quest Diagnostics Incorporated</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>1290 Wall Street West</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>Lyndhurst, NJ 07071</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(201) 393-5000</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>Delaware</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(State of Incorporation)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>16-1387862</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>(I.R.S. Employer Identification Number)</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;border-bottom:solid black 1px'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">
<DIV STYLE="page-break-after:always"></DIV><PAGE>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'>
<b><font size=2>Item 1.01.  Entry into a Material Definitive Agreement</font></b></p>

<p style=' margin-bottom:5pt; margin-top:5pt; text-indent:8%;text-align:left;'><font size=2>On July 31, 2006, Quest Diagnostics Incorporated (the &#147;Company&#148;), and Focus Technologies Holding Company and Focus Diagnostics, Inc.  (collectively, the &#147;Additional Subsidiary Guarantors&#148;), certain of the Company&#146;s subsidiaries and The Bank of New York, as Trustee, entered into the Eighth Supplemental Indenture.  The Eighth Supplemental Indenture supplements the indenture dated as of June 27, 2001 among the guarantors (as defined therein) and the Trustee, as subsequently supplemented by a first supplemental indenture, dated as of June 27, 2001, as further supplemented by a second supplemental indenture, dated as of November 26, 2001, as further supplemented by a third supplemental indenture, dated as of April 4, 2002, as further supplemented by a fourth supplemental indenture, dated as of March 19, 2003, as further supplemented by a fifth supplemental indenture, dated as
of April 16, 2004, as further supplemented by a sixth supplemental indenture dated October 31, 2005, and as further supplemented by a seventh supplemental indenture dated November 21, 2005 (collectively, the &#147;Indenture&#148;). </font></p>

<p style=' margin-bottom:5pt; margin-top:5pt; text-indent:8%;text-align:left;'><font size=2>The Eighth Supplemental Indenture adds the Additional Subsidiary Guarantors, which became subsidiaries of the Company on July 3, 2006, as guarantors to the Company&#146;s 7&#189;% Senior Notes due 2011, 5.125% Senior Notes due 2010 and 5.45% Senior Notes due 2015 issued pursuant to the Indenture.  The Eighth Supplemental Indenture is attached hereto as exhibit 4.1.</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt; text-indent:7.69%;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>  </font><b><font size=2>Item 9.01.  Financial Statements and Exhibits</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr>
    <td width="8%"><font size=2>c.</font></td>
    <td width="8%"><u><font size=2>Exhibits </font></u></td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr valign="top">
    <td>&nbsp;</td>
    <td><font size=2>4.1</font></td>
    <td><font size=2>Eighth Supplemental Indenture, dated as of July 31, 2006,
      among the Company, the guarantors named therein and The Bank of New York,
      as Trustee.</font></td>
  </tr>
</table>
<p style=' margin-bottom:0pt; margin-top:0pt; margin-left:7.69%;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'>
</p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<table border="0" cellspacing=0 cellpadding=0 width="53%" style='border-collapse:collapse'>
    <tr >
        <td width="91%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>&nbsp;</p> </td>
        <td width="8%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>2</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">
<DIV STYLE="page-break-after:always"></DIV><PAGE>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;border-bottom:solid black 1px'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><b><font size=2>Signature</font></b></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt; text-indent:8.62%;text-align:left;'><font size=2>Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr>
    <td>&nbsp;</td>
    <td colspan="2"><font size=2>August 2, 2006</font></td>
    <td width="15%">&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td colspan="2">&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td colspan="3">&nbsp;</td>
  </tr>
  <tr>
    <td width="55%"><font size="2">&nbsp;</font></td>
    <td colspan="3"><font SIZE=2>QUEST DIAGNOSTICS INCORPORATED&nbsp;</font></td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="5%"><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">By:</font></td>
    <td style='border-bottom:solid black 1px'><font size="2">/s/ Leo C. Farrenkopf,
      Jr. &nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td colspan="2"><font size="2">Leo C. Farrenkopf, Jr.<br>
      Vice President and Assistant Secretary</font><font size="2">&nbsp;</font></td>
  </tr>
</table>
<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font><font size=2>&nbsp;</font></p>


<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;border-bottom:solid black 1px'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<table border="0" cellspacing=0 cellpadding=0 width="53%" style='border-collapse:collapse'>
    <tr >
        <td width="91%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>&nbsp;</p> </td>
        <td width="8%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>3</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">

</BODY>
</HTML>

</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4
<SEQUENCE>2
<FILENAME>ex4-1.htm
<DESCRIPTION>EXHIBIT 4.1
<TEXT>
<HTML>
<HEAD>
<TITLE></TITLE>
</HEAD>
<BODY>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:right;'>
<b><font size=2>Exhibit 4.1</font></b></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>EIGHTH SUPPLEMENTAL INDENTURE</font></B></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:center;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>SUPPLEMENTAL INDENTURE dated as of July 31, 2006  (this &#147;Eighth  Supplemental Indenture&#148;), among FOCUS TECHNOLOGIES HOLDING COMPANY, and FOCUS DIAGNOSTICS, INC., each  a Delaware corporation, (collectively, the &#147;Additional Subsidiary Guarantors&#148;), QUEST DIAGNOSTICS INCORPORATED, a Delaware corporation (the &#147;Company&#148;), THE BANK OF NEW YORK, a New York banking corporation as Trustee (the &#147;Trustee&#148;), and the Subsidiary Guarantors (as defined in the Indenture referred to herein).</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:center;'><B><font SIZE=2>RECITALS OF THE COMPANY</font></B></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>WHEREAS, the Company, the Trustee and the Initial Subsidiary Guarantors (as hereinafter defined) executed and delivered an Indenture, dated as of June&nbsp;27, 2001 (the &#147;Base Indenture&#148;), as supplemented by the first supplemental indenture, dated as of June 27, 2001, among the Company, the Initial Subsidiary Guarantors (as defined therein) party thereto, and the Trustee, as further supplemented by a second supplemental indenture, dated as of November 26, 2001, among the Company, the Subsidiary Guarantors (as defined therein) party thereto and the Trustee, as further supplemented by a third supplemental indenture, dated as of April 4, 2002, among the Company, the additional Subsidiary Guarantors (as defined therein) party thereto and the Trustee, as further supplemented by a fourth supplemental indenture, dated as of March 19, 2003, among the Company, the additional Subsidiary
Guarantors (as defined therein) party thereto and the Trustee, as further supplemented by a fifth supplemental indenture, dated as of April 16, 2004, among the Company, the additional Subsidiary Guarantor (as defined therein) party thereto and the Trustee, as further supplemented by a sixth supplemental indenture dated October 31, 2005, among the Company, the Subsidiary Guarantors (as defined therein) party thereto, as further supplemented by a seventh supplemental indenture dated November 21, 2005, among the Company, the additional Subsidiary Guarantors (as defined therein) parties thereto and the Trustee, and to be further supplemented by this Eighth Supplemental Indenture (collectively, the &#147;Indenture&#148;), to provide for the issuance by the Company from time to time of Securities to be issued in one or mores series as provided in the Indenture;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>WHEREAS, the Additional Subsidiary Guarantors intend to guarantee the Securities under the Indenture and the issuance of guarantees has been authorized by resolutions adopted by the Boards of Directors and/or Managers, as applicable, of such Additional Subsidiary Guarantors; </font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>WHEREAS, Sections 901(1) and 901(11) of the Indenture provide that without the consent of Holders of the Securities of any series issued under the Indenture, the Company and the Subsidiary Guarantors, when authorized by a Board Resolution, and the Trustee may enter into one or more indentures supplemental to the Indenture to (a) evidence the successor of another Person to any Subsidiary Guarantor and the assumption by such successor of the covenants of such Subsidiary Guarantor in the Indenture and in the Securities and (b) add a guarantor or guarantors for any series or all series of the Securities;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<table border="0" cellspacing=0 cellpadding=0 width="53%" style='border-collapse:collapse'>
    <tr >
        <td width="91%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>&nbsp;</p> </td>
        <td width="8%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>1</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">
<DIV STYLE="page-break-after:always"></DIV><PAGE>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>WHEREAS, pursuant to Sections 904, 1601, 1602 and 1604 of the Indenture, by delivery of a Supplemental Indenture to the Trustee in accordance with the terms of the Indenture, each Person that becomes a Subsidiary Guarantor after the date of the Base Indenture will be deemed to have executed and delivered the Subsidiary Guarantee for the benefit of the Holder of the Security upon which the Subsidiary Guarantee is endorsed, with the same effect as if such Subsidiary Guarantor had been named thereon and had executed and delivered the Subsidiary Guarantee; and</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>WHEREAS, all things necessary to make this Eighth Supplemental Indenture a valid supplement to the Indenture according to its terms and the terms of the Indenture have been done;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>NOW,
  THEREFORE, for and in consideration of the foregoing, the parties hereto hereby
  enter into this Eighth Supplemental Indenture, for the equal and proportionate
  benefit of all Holders of the Securities, as follows:</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  1&nbsp;&nbsp;</font><u><font size=2>Certain Terms Defined in the Indenture</font></u><font size=2>.</font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>All
  capitalized terms used but not defined herein shall have the meanings assigned
  to them in the Indenture.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  2&nbsp;&nbsp;</font><u><font size=2>Agreement to Guarantee</font></u><font size=2>.</font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>The
  Additional Subsidiary Guarantors, by their signatures below, agree to become
  Additional Subsidiary Guarantors under the Indenture with the same force and
  effect as if originally named therein as Subsidiary Guarantors. The Additional
  Subsidiary Guarantors hereby agree to all the terms and provisions of the Indenture
  applicable to them as Additional Subsidiary Guarantors thereunder and each reference
  to a &#147;Subsidiary Guarantor&#148; in the Indenture shall be deemed to include
  the Additional Subsidiary Guarantors.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  3&nbsp;&nbsp;<u><font size=2>Indenture Remains in Full Force and Effect</font></u><font size=2>.</font></font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>Except
  as expressly supplemented by this Eighth Supplemental Indenture, the Indenture
  shall remain in full force and effect in accordance with its terms.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  4&nbsp;&nbsp;<u><font size=2>New York Law to Govern</font></u><font size=2>.</font></font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>THIS
  EIGHTH SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE
  WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO PRINCIPLES OF CONFLICT
  OF LAWS.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  5&nbsp;&nbsp;</font><u><font size=2>Separability</font></u><font size=2>.</font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>In case any one or more of the provisions contained in this Eighth Supplemental Indenture should be held invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein and in the Indenture shall not in any way be affected or impaired.  The parties hereto shall endeavor in good faith negotiations to replace any invalid, illegal or enforceable provisions herein with valid provisions, the economic </font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<table border="0" cellspacing=0 cellpadding=0 width="53%" style='border-collapse:collapse'>
    <tr >
        <td width="91%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>&nbsp;</p> </td>
        <td width="8%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>2</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">
<DIV STYLE="page-break-after:always"></DIV><PAGE>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:12pt; margin-top:0pt;text-align:left;'><font size=2>effect
  of which comes as close as possible to that of the invalid, illegal or unenforceable
  provisions.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>SECTION
  6&nbsp;&nbsp;</font><u><font size=2>May be Executed in Counterparts</font></u><font size=2>.</font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>This
  Eighth Supplemental Indenture may be executed in counterparts, each of which
  when taken together shall constitute one and the same instrument. This Eighth
  Supplemental Indenture shall become effective when the Trustee shall have received
  a counterpart thereof that bears the signatures of each of the Additional Subsidiary
  Guarantors.</font></p>
<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font SIZE=2>SECTION
  7&nbsp;&nbsp;</font><u><font size=2>Trustee</font></u>.</p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>The Trustee makes no representations as to the validity or sufficiency of this Eighth Supplemental Indenture.  The recitals and statements herein are deemed to be those of the Company and the Additional Subsidiary Guarantors and not of the Trustee. </font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<table border="0" cellspacing=0 cellpadding=0 width="53%" style='border-collapse:collapse'>
    <tr >
        <td width="91%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'>&nbsp;</p> </td>
        <td width="8%" nowrap valign=top >
            <p style='margin-left:0pt;text-indent:0pt;text-align:left;margin-top:0pt;margin-bottom:0pt'><font size=2>3</font></p> </td> </tr></table>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>
<br>
<HR noshade align="center" width="100%" size="2">
<DIV STYLE="page-break-after:always"></DIV><PAGE>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:0pt; margin-top:0pt;text-align:left;'><font size=2>&nbsp;</font></p>


<p style=' margin-bottom:12pt; margin-top:0pt; text-indent:15.38%;text-align:left;'><font size=2>IN WITNESS WHEREOF, the Company, the Additional Subsidiary Guarantors and the Trustee have duly executed this Eighth Supplemental Indenture as of the day and year first above written.</font></p>

<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr>
    <td width="55%"><font size="2">&nbsp;</font></td>
    <td colspan="2"><font SIZE=2>QUEST DIAGNOSTICS INCORPORATED</font></td>
    <td width="15%"><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td width="4%">&nbsp;</td>
    <td width="26%">&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">By:</font></td>
    <td style='border-bottom:solid black 1px'><font size=2> /s/ Joseph P. Manory</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">&nbsp;</font></td>
    <td colspan="2"><font size="2">Name: Joseph P. Manory<br>
      Title: Vice President and Treasurer</font><font size="2">&nbsp;</font></td>
  </tr>
</table>
<p style=' margin-bottom:36pt; margin-top:0pt; margin-left:46.15%;text-align:left;'>&nbsp;
</p>
<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr>
    <td>&nbsp;</td>
    <td colspan="3"><font SIZE=2>FOCUS TECHNOLOGIES HOLDING COMPANY</font></td>
  </tr>
  <tr>
    <td width="55%"><font size="2">&nbsp;</font></td>
    <td colspan="2"><font SIZE=2>FOCUS DIAGNOSTICS, INC., as Additional Subsidiary
      Guarantors </font></td>
    <td width="7%"><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td>&nbsp;</td>
    <td>&nbsp;</td>
    <td width="34%">&nbsp;</td>
    <td>&nbsp;</td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">By:</font></td>
    <td style='border-bottom:solid black 1px'><font size=2> /s/ Joseph P. Manory</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td colspan="2"><font size="2">Name: Joseph P. Manory<br>
      Title: Vice President and Treasurer</font><font size="2">&nbsp;</font></td>
  </tr>
</table>
<p style=' margin-bottom:0pt; margin-top:0pt; margin-left:46.15%;text-align:left;'><font size=2>&nbsp;</font></p>

<p style=' margin-bottom:36pt; margin-top:0pt; margin-left:46.15%;text-align:left;'>&nbsp;</p>

<table width="100%" border="0" cellspacing="0" cellpadding="0">
  <tr>
    <td>&nbsp;</td>
    <td colspan="3"><font size=2>THE BANK OF NEW YORK, as Trustee</font></td>
  </tr>
  <tr>
    <td width="55%"><font size="2">&nbsp;</font></td>
    <td colspan="2">&nbsp;</td>
    <td width="15%"><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">&nbsp;</font></td>
    <td width="26%"><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td width="4%"><font size="2">By:</font></td>
    <td style='border-bottom:solid black 1px'><font size=2> /s/ Robert A. Massimillo</font></td>
    <td><font size="2">&nbsp;</font></td>
  </tr>
  <tr>
    <td><font size="2">&nbsp;</font></td>
    <td><font size="2">&nbsp;</font></td>
    <td colspan="2"><font size="2">Name: Robert A. Massimillo<br>
      Title: </font><font size=2>Vice President</font></td>
  </tr>
</table>
<p style=' margin-bottom:36pt; margin-top:0pt; margin-left:46.15%;text-align:left;'><font size=2>&nbsp;</font></p>

<HR noshade align="center" width="100%" size="2">
<p style=' margin-bottom:0pt; margin-top:0pt; margin-left:46.15%;text-align:left;'>&nbsp;</p>

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
