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Agreements With University Of Maryland And Duke University - Additional information (Detail) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Feb. 01, 2021 | Jul. 31, 2016 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2020 | Dec. 31, 2016
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Common stock, capital shares reserved for future issuance |  |  | 73,863,844 | 82,654,698 |  |  |
Research and development expense |  |  | $ 136,827 | $ 92,321 | $ 43,978 |  |
Option Agreement [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Agreement, option to extend |  |  | extend another year |  |  |  |
Option Agreement [Member] | University Of Maryland [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Agreement term |  |  |  |  |  |  | 5 years
Common stock, capital shares reserved for future issuance |  |  |  |  |  |  | 642,995
Option Agreement [Member] | Duke [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Research and development expense |  |  | $ 500 | $ 500 | $ 500 |  |
Option Agreement [Member] | University Of Maryland And Duke [Member] | Patents [Member] | Initial Patents Received [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Stock issued during the period purchase of assets |  | 142,886 |  |  |  |  |
Amended License Agreement [Member] | University Of Maryland [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Option agreement indexed to equity, shares available for issuance, fair value | $ 1,600 |  |  |  |  |  |
Amended License Agreement [Member] | University Of Maryland [Member] | Common Stock [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Stock issued during the period purchase of assets | 257,198 |  |  |  |  |  |
Amended Option Agreement [Member] | Duke [Member] | Common Stock [Member] |  |  |  |  |  |  |
Agreement Disclosure [Line Items] |  |  |  |  |  |  |
Option agreement, remaining number of shares available for issuance |  |  |  |  |  | 1,214,317 |

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