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Indirect Cash Flow (Details) - USD ($) $ in Thousands | 6 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2020 | Jun. 17, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Supplemental Cash Flow Elements [Abstract] |  |  |  |  |
Net income (loss) | $ 1,077,069 | $ 624,885 | $ 1,241,201 | $ 1,701,954 | $ 2,461,419
Adjustments to reconcile consolidated net income to net cash provided by operating activities: |  |  |  |  |
Income from financial royalty assets |  |  | (2,065,083) | (1,959,975) | (1,648,837)
Provision for changes in expected cash flows from financial royalty assets |  |  | 452,842 | 230,839 | (1,019,321)
Amortization of intangible assets |  |  | 22,996 | 23,058 | 23,924
Amortization of debt discount and issuance costs |  |  | 20,162 | 11,715 | 12,790
Losses on derivative financial instruments |  |  | 21,532 | 42,076 | 39,138
Losses/(gains) on equity securities |  |  | 48,066 | (247,073) | (155,749)
Equity in losses/(earnings) of non-consolidated affiliates |  |  | 19,490 | (44,459) | 32,517
Distributions from non-consolidated affiliates |  |  | 34,384 | 42,334 | 14,059
Loss on extinguishment of debt |  |  | 358 | 30,272 | 0
Share-based compensation |  |  | 2,443 | 5,428 | 0
Interest income accretion |  |  | (50,896) | (20,551) | 0
Unrealized gains on available for sale debt securities |  |  | (17,859) | (18,600) | 0
Impairment charge |  |  | 0 | 65,053 | 0
Termination of derivative financial instruments |  |  | (16,093) | (34,952) | 0
Other |  |  | 4,461 | 9,621 | (2,122)
Decrease/(increase) in operating assets: |  |  |  |  |
Cash collected on financial royalty assets |  |  | 2,315,854 | 2,121,923 | 1,934,092
Available for sale debt securities |  |  | 0 | 0 | (150,000)
Accrued royalty receivable |  |  | (20,131) | 370 | 2,471
Other receivables |  |  | 0 | 0 | 150,000
Other royalty income receivable |  |  | (9,012) | (770) | 7,390
Other current assets and other assets |  |  | 1,857 | 34,986 | (41,028)
(Decrease)/increase in operating liabilities: |  |  |  |  |
Accounts payable and accrued expenses |  |  | (4,586) | (766) | 6,496
Interest payable |  |  | 15,550 | 42,146 | 0
Net cash provided by operating activities |  |  | 2,017,536 | 2,034,629 | 1,667,239
Supplemental Schedule of Non-cash Investing/Financing Activities: |  |  |  |  |
Receipt of contribution of investments in Legacy Investors Partnerships |  |  | 0 | 303,679 | 0
Settlement of Epizyme forward purchase contract |  |  | 0 | 5,700 | 0
Accrued purchase obligation - Tazverik |  |  | 0 | 110,000 | 0
Repayments of long-term debt by contributions from non-controlling interest |  |  | 0 | 1,103,774 | 0
Milestone payable - Erleada |  |  | $ 0 | $ 18,600 | $ 0

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