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Fair Value Measurements and Financial Instruments - Narrative (Details) - USD ($) $ in Millions |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Apr. 05, 2019 | Nov. 30, 2021 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] |  |  |  |  |
Unrealized gain (loss) on equity securities still held |  |  | $ 60.1 | $ 85.4 | $ (104.4)
Restrictions on selling common stock, period |  |  | 6 months |  |
Level 3 | BioCryst Pharmaceuticals, Inc. |  |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] |  |  |  |  |
Number of shares purchased (in shares) |  | 3,846,000 |  |  |
Preferred Shares | Debt Securities |  |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] |  |  |  |  |
Redemption price, percentage | 200.00% |  |  |  |
Preferred shares, quarterly payments |  |  | $ 15.6 |  |
Preferred shares, fixed payment amount |  |  | $ 250.0 |  |
Change in control event, period |  |  | 4 years |  |
Preferred shares, weighted average cost of capital |  |  | 9.50% | 8.30% |
Number of shares purchased (in shares) | 2,495 |  |  |  |
Preferred Shares | Maximum | Redemption, Period One |  |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] |  |  |  |  |
Redemption price, percentage | 200.00% |  |  |  |
Preferred Shares | Maximum | Redemption, Period One | Debt Securities |  |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] |  |  |  |  |
Redemption price, percentage | 200.00% |  |  |  |

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