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Fair Value Measurements and Financial Instruments (Tables)
12 Months Ended
Dec. 31, 2021
Fair Value Disclosures [Abstract]  
Schedule of Fair Value Hierarchy
The following table summarizes financial assets and financial liabilities that we measured at fair value on a recurring basis at the dates indicated, classified in accordance with the fair value hierarchy described above (in thousands):

As of December 31, 2021As of December 31, 2020
Level 1Level 2Level 3TotalLevel 1Level 2Level 3Total
Assets:
Cash equivalents
Money market funds$598,253 $— $— $598,253 $24,302 $— $— $24,302 
Commercial paper— 13,997 — 13,997 — 77,176 — 77,176 
Certificates of deposit— 40,954 — 40,954 — 74,502 — 74,502 
Marketable securities
Corporate debt securities— — — — — 32,754 — 32,754 
Commercial paper— 207,457 — 207,457 — 444,554 — 444,554 
Certificates of deposit— 374,415 — 374,415 — 505,971 — 505,971 
Available for sale debt securities— — 66,000 66,000 — — 69,984 69,984 
Total current assets$598,253 $636,823 $66,000 $1,301,076 $24,302 $1,134,957 $69,984 $1,229,243 
Equity securities226,787 — 43,013 269,800 298,689 — — 298,689 
Available for sale debt securities— — 187,700 187,700 — — 144,416 144,416 
Forwards (1)— — 16,700 16,700 — — 18,600 18,600 
Warrant (2)— — — — — 5,439 — 5,439 
Total non-current assets$226,787 $ $247,413 $474,200 $298,689 $5,439 $163,016 $467,144 
(1)The balance as of December 31, 2021 includes Series B Forwards and the Development Funding Bond Forward, recorded within Available for sale debt securities in the consolidated balance sheet, related to our obligations to fund acquisitions of the Series B Biohaven Preferred Shares and $150 million of the Development Funding Bonds, respectively. The balance as of December 31, 2020 relates to Series B Forwards, recorded within Available for sale debt securities in the consolidated balance sheet. See Note 3–Available for Sale Debt Securities for additional discussion.
(2)Related to the Epizyme transaction as described in Note 4–Derivative Instruments and recorded in Other assets in the consolidated balance sheets as of December 31, 2021 and 2020. The fair value of the warrant was not material as of December 31, 2021.
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation
The tables presented below summarize the change in the combined fair value (current and non-current) of Level 3 financial instruments, which relate to equity securities and available for sale debt securities, including the underlying debt securities and related forwards (in thousands).

Years Ended December 31,
20212020
Equity Securities
Balance at the beginning of the year$— $— 
Purchases35,120 — 
Gains on equity securities7,893 — 
Balance at the end of the year$43,013 $ 
Years Ended December 31,
20212020
Debt Securities
Balance at the beginning of the year$214,400 $131,280 
Purchases70,441 — 
Unrealized gains on available for sale debt securities (1)12,900 52,725 
Settlement of forwards (2)18,459 — 
Transfer to Level 2— (184,005)
Transfer from Level 2 (3)— 198,526 
Unrealized gains on available for sale debt securities (1)— 15,874 
Redemption(62,500)— 
Balance at the end of the year$253,700 $214,400 
Years Ended December 31,
20212020
Forwards
Balance at the beginning of the year$18,600 $— 
Unrealized gains (4)16,559 18,600 
Settlement of forwards (2)(18,459)— 
Balance at the end of the year$16,700 $18,600 
(1)For the year ended December 31, 2021, the unrealized gains on available for sale debt securities is comprised of $11.6 million related to Series A Biohaven Preferred Shares as recorded on the consolidated statements of comprehensive income and $1.3 million related to the Series B Biohaven Preferred Shares as recorded on the consolidated statements of operations. For the year ended December 31, 2020, the unrealized gains on available for sale debt securities related to the Series A Biohaven Preferred Shares as recorded on the consolidated statements of comprehensive income, including $52.7 million prior to transferring out of Level 3 and then $15.9 million after transferring back to Level 3.     
(2)Reflects the fair value attributed to the Series B Forwards that were settled in the period as the Series B Biohaven Preferred Shares were acquired, which is included in the fair value of the Series B Biohaven Preferred Shares. See Note 3–Available for Sale Debt Securities.
(3)Includes $14.5 million of unrealized gains on available for sale debt securities included in other comprehensive income while the Series A Biohaven Preferred Shares was classified as a Level 2 asset.
(4)Recorded within Unrealized gains on available for sale debt securities on the consolidated statements of operations.
Fair Value Disclosure of Asset and Liability Not Measured at Fair Value Estimated fair values based on Level 3 inputs and related carrying values for our financial royalty assets as of December 31, 2021 and 2020 are presented below (in thousands).
December 31, 2021December 31, 2020
Fair ValueCarrying Value, netFair ValueCarrying Value, net
Financial royalty assets, net$19,047,183 $14,332,596 $18,718,179 $12,955,277