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Non-Consolidated Affiliates (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Jul. 31, 2021	Feb. 11, 2020	May 31, 2018	Mar. 31, 2017
Schedule of Equity Method Investments [Line Items]
Investments in non-consolidated affiliates	$ 435,394	$ 454,936
Equity in income (loss) of non-consolidated affiliates	(19,490)	44,459	$ (32,517)
Distributions from non-consolidated affiliates	523	15,084	0
Distributions from non-consolidated affiliates	34,384	42,334	14,059
Avillion II | Merck Asset - Phase II Clinical Trial
Schedule of Equity Method Investments [Line Items]
Other commitment				$ 122,500		$ 105,000	$ 19,000
Other commitments, percentage of costs (as a percent)							50.00%
Avillion II | AZ Asset - Phase II and Phase III Clinical Trial
Schedule of Equity Method Investments [Line Items]
Other commitments, percentage of costs (as a percent)						44.00%
Equity Method Investment, Nonconsolidated Investee or Group of Investees | Legacy Investors Partnerships
Schedule of Equity Method Investments [Line Items]
Investments in non-consolidated affiliates					$ 303,700
Equity in income (loss) of non-consolidated affiliates	8,900	62,000
Distributions from non-consolidated affiliates	21,000	22,700
Equity Method Investment, Nonconsolidated Investee or Group of Investees | Avillion Entities
Schedule of Equity Method Investments [Line Items]
Equity in income (loss) of non-consolidated affiliates	(28,400)	(17,600)	(32,500)
Equity method investment, unfunded commitments	(11,200)	28,600
Equity Method Investment, Nonconsolidated Investee or Group of Investees | Avillion I
Schedule of Equity Method Investments [Line Items]
Distributions from non-consolidated affiliates	$ 13,400	13,400	$ 14,100
Equity Method Investment, Nonconsolidated Investee or Group of Investees | Avillion II
Schedule of Equity Method Investments [Line Items]
Distributions from non-consolidated affiliates		$ 21,300

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