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Fair Value Measurements and Financial Instruments (Tables)
6 Months Ended
Jun. 30, 2022
Fair Value Disclosures [Abstract]  
Schedule of Fair Value Hierarchy
The following table summarizes assets and liabilities measured at fair value on a recurring basis at the dates indicated, classified in accordance with the fair value hierarchy described above (in thousands):
As of June 30, 2022As of December 31, 2021
Level 1Level 2Level 3TotalLevel 1Level 2Level 3Total
Assets:
Cash equivalents
Money market funds$307,797 $— $— $307,797 $598,253 $— $— $598,253 
Commercial paper— 181,681 — 181,681 — 13,997 — 13,997 
Certificates of deposit— 36,001 — 36,001 — 40,954 — 40,954 
Marketable securities
Commercial paper— 87,622 — 87,622 — 207,457 — 207,457 
Certificates of deposit— 178,766 — 178,766 — 374,415 — 374,415 
U.S. government securities— 24,014 — 24,014 — — — — 
Available for sale debt securities
Debt securities (1)— — 300,000 300,000 — — 66,000 66,000 
Forwards (2)— — 63,700 63,700 — — — — 
Derivative instrument (3)— — 63,200 63,200 — — — — 
Total current assets$307,797 $508,084 $426,900 $1,242,781 $598,253 $636,823 $66,000 $1,301,076 
Equity securities275,662 — 28,785 304,447 226,787 — 43,013 269,800 
Available for sale debt securities
Debt securities (1)— — 63,000 63,000 — — 187,700 187,700 
Forwards (2)— — — — — — 16,700 16,700 
Derivative instrument (3)— — 8,600 8,600 — — — — 
Royalty at fair value (4)— — 21,215 21,215 — — — — 
Total non-current assets$275,662 $ $121,600 $397,262 $226,787 $ $247,413 $474,200 
Liabilities:
Available for sale debt securities
Forwards (2)— — (35,600)(35,600)— — — — 
Funding commitments (5)— — (8,100)(8,100)— — — — 
Total non-current liabilities$ $ $(43,700)$(43,700)$ $ $ $ 
(1)Reflects the fair value of the Series A Biohaven Preferred Shares and Series B Biohaven Preferred Shares. As of June 30, 2022, amounts also include the fair value of the funded portion of the Cytokinetics Commercial Launch Funding.
(2)Reflects the fair value of our obligations to fund the acquisitions of the Series B Biohaven Preferred Shares as recorded within current assets as of June 30, 2022 and within non-current assets as of December 31, 2021. As of December 31, 2021, the amount also reflects the fair value of our obligations to fund the Development Funding Bonds as recorded within non-current assets. As of June 30, 2022, the fair value of our obligations to fund the Development Funding Bonds was reflected within Other liabilities on the condensed consolidated balance sheet.
(3)Related to the Milestone Acceleration Option (defined below) recorded within Other current assets and Other assets on the condensed consolidated balance sheet.
(4)Recorded within Other assets on the condensed consolidated balance sheet. See Note 8–Non-Consolidated Affiliates for additional discussion.
(5)Related to the fair value of the Cytokinetics Funding Commitments as reflected within Other liabilities on the condensed consolidated balance sheet as of June 30, 2022.
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation
The table presented below summarizes the change in the combined fair value (current and non-current) of Level 3 financial instruments, which relate to equity securities, a royalty interest, a derivative instrument and available for sale debt securities, including the underlying debt securities, related forwards and funding commitments (in thousands):

For the Three Months Ended June 30, 2022For the Three Months Ended June 30, 2021
Equity SecuritiesDebt SecuritiesForwardsFunding CommitmentsDerivative InstrumentRoyalty at Fair ValueDebt SecuritiesForwards
Balance at the beginning of the period$62,538 $314,000 $(1,200)$(8,400)$ $ $226,800 $22,400 
Purchases28,785 14,579 — — — 21,215 17,585 — 
Losses on equity securities(21,846)— — — — — — — 
Gains on derivative financial instrument— — — — 71,800 — — — 
Unrealized gains included in other comprehensive losses (1) — 9,325 — — — — 6,025 — 
Unrealized gains included in earnings (2)— 31,800 38,221 300 — — 500 13,515 
Settlement of forwards (3)— 8,921 (8,921)— — — 5,115 (5,115)
Transfer to Level 1 (4)(40,692)— — — — — — — 
Redemption of debt securities— (15,625)— — — — (15,625)— 
Balance at the end of the period$28,785 $363,000 $28,100 $(8,100)$71,800 $21,215 $240,400 $30,800 
(1)Recorded within Unrealized gains on available for sale debt securities in the condensed consolidated statements of comprehensive income for unrealized gains related to Series A Biohaven Preferred Shares.
(2)Recorded within Unrealized gains on available for sale debt securities in the condensed consolidated statements of operations for the unrealized change in fair value in the Series B Biohaven Preferred Shares, Series B Forwards and the Development Funding Bond Forward. For the three months ended June 30, 2022, amounts also reflect unrealized change in fair value in the funded portion of the Cytokinetics Commercial Launch Funding and the Cytokinetics Funding Commitments.
(3)Reflects the fair value attributed to the Series B Forwards that were settled simultaneously with the acquisition of the Series B Biohaven Preferred Shares, which is included in the fair value of the Series B Biohaven Preferred Shares.
(4)Related to transfer restriction expiration of BioCryst common stock.

For the Six Months Ended June 30, 2022For the Six Months Ended June 30, 2021
Equity SecuritiesDebt SecuritiesForwardsFunding CommitmentsDerivative InstrumentRoyalty at Fair ValueDebt SecuritiesForwards
Balance at the beginning of the period$43,013 $253,700 $16,700 $ $ $ $214,400 $18,600 
Purchases28,785 79,158 — — — 21,215 35,170 — 
Gains/(losses) on initial recognition (1)— 9,400 — (9,400)— — — — 
Losses on equity securities(2,321)— — — — — — — 
Gains on derivative financial instrument— — — — 71,800 — — — 
Unrealized gains included in other comprehensive losses (2) — 10,950 — — — — 11,150 — 
Unrealized gains included in earnings (3)— 30,200 22,242 1,300 — — 500 22,630 
Settlement of forwards (4)— 10,842 (10,842)— — — 10,430 (10,430)
Transfer to Level 1 (5) (40,692)— — — — — — — 
Redemption of debt securities— (31,250)— — — — (31,250)— 
Balance at the end of the period$28,785 $363,000 $28,100 $(8,100)$71,800 $21,215 $240,400 $30,800 
(1)Represents purchase price allocation to arrive at the appropriate fair value on initial recognition.
(2)Recorded within Unrealized gains on available for sale debt securities in the condensed consolidated statements of comprehensive income for unrealized gains related to Series A Biohaven Preferred Shares.
(3)Recorded within Unrealized gains on available for sale debt securities in the condensed consolidated statements of operations for the unrealized change in fair value in the Series B Biohaven Preferred Shares, Series B Forwards and the Development Funding Bond Forward. For the six months ended June 30, 2022, amounts also reflect the unrealized change in fair value in the funded portion of the Cytokinetics Commercial Launch Funding and the Cytokinetics Funding Commitments.
(4)Reflects the fair value attributed to the Series B Forwards that were settled simultaneously with the acquisition of the Series B Biohaven Preferred Shares, which is included in the fair value of the Series B Biohaven Preferred Shares.
(5)Related to transfer restriction expiration of BioCryst common stock.
Fair Value Disclosure of Asset and Liability Not Measured at Fair Value Estimated fair values based on Level 3 inputs and related carrying values for the non-current portion of financial royalty assets as of June 30, 2022 and December 31, 2021 are presented below (in thousands):
As of June 30, 2022As of December 31, 2021
Fair ValueCarrying Value, netFair ValueCarrying Value, net
Financial royalty assets, net$18,254,440 $13,423,629 $19,047,183 $13,718,245