Fair Value Measurements and Financial Instruments - Schedule of Fair Value Hierarchy (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Assets:
Marketable securities	$ 290,402	$ 581,872
Available for sale debt securities	363,700	66,000
Equity securities	304,447	269,800
Available for sale debt securities	63,000	204,400
Liabilities:
Available for sale debt securities, liabilities current	0	0
Available for sale debt securities, liabilities noncurrent	(43,700)	0
Fair Value, Recurring
Assets:
Derivative instrument, current	63,200	0
Total current assets	1,242,781	1,301,076
Equity securities	304,447	269,800
Derivative financial instruments	8,600	0
Total non-current assets	397,262	474,200
Liabilities:
Available for sale debt securities, liabilities noncurrent	(43,700)	0
Fair Value, Recurring \| Royalty Investments
Assets:
Available for sale debt securities	21,215	0
Fair Value, Recurring \| Cytokinetics Funding Commitment
Liabilities:
Available for sale debt securities, liabilities current	(8,100)	0
Level 1 \| Fair Value, Recurring
Assets:
Derivative instrument, current	0	0
Total current assets	307,797	598,253
Equity securities	275,662	226,787
Derivative financial instruments	0	0
Total non-current assets	275,662	226,787
Liabilities:
Available for sale debt securities, liabilities noncurrent	0	0
Level 1 \| Fair Value, Recurring \| Royalty Investments
Assets:
Available for sale debt securities	0	0
Level 1 \| Fair Value, Recurring \| Cytokinetics Funding Commitment
Liabilities:
Available for sale debt securities, liabilities current	0	0
Level 2 \| Fair Value, Recurring
Assets:
Derivative instrument, current	0	0
Total current assets	508,084	636,823
Equity securities	0	0
Derivative financial instruments	0	0
Total non-current assets	0	0
Liabilities:
Available for sale debt securities, liabilities noncurrent	0	0
Level 2 \| Fair Value, Recurring \| Royalty Investments
Assets:
Available for sale debt securities	0	0
Level 2 \| Fair Value, Recurring \| Cytokinetics Funding Commitment
Liabilities:
Available for sale debt securities, liabilities current	0	0
Level 3 \| Fair Value, Recurring
Assets:
Derivative instrument, current		0
Total current assets	426,900	66,000
Equity securities	28,785	43,013
Derivative financial instruments		0
Total non-current assets	121,600	247,413
Liabilities:
Available for sale debt securities, liabilities noncurrent	(43,700)	0
Level 3 \| Fair Value, Recurring \| Milestone Acceleration
Assets:
Derivative instrument, current	63,200
Derivative financial instruments	8,600
Level 3 \| Fair Value, Recurring \| Royalty Investments
Assets:
Available for sale debt securities	21,215	0
Level 3 \| Fair Value, Recurring \| Cytokinetics Funding Commitment
Liabilities:
Available for sale debt securities, liabilities current	(8,100)	0
Commercial paper \| Fair Value, Recurring
Assets:
Marketable securities	87,622	207,457
Commercial paper \| Level 1 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
Commercial paper \| Level 2 \| Fair Value, Recurring
Assets:
Marketable securities	87,622	207,457
Commercial paper \| Level 3 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
Certificates of deposit \| Fair Value, Recurring
Assets:
Marketable securities	178,766	374,415
Certificates of deposit \| Level 1 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
Certificates of deposit \| Level 2 \| Fair Value, Recurring
Assets:
Marketable securities	178,766	374,415
Certificates of deposit \| Level 3 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
U.S. government securities \| Fair Value, Recurring
Assets:
Marketable securities	24,014	0
U.S. government securities \| Level 1 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
U.S. government securities \| Level 2 \| Fair Value, Recurring
Assets:
Marketable securities	24,014	0
U.S. government securities \| Level 3 \| Fair Value, Recurring
Assets:
Marketable securities	0	0
Debt Securities \| Fair Value, Recurring
Assets:
Available for sale debt securities	300,000	66,000
Available for sale debt securities	63,000	187,700
Debt Securities \| Level 1 \| Fair Value, Recurring
Assets:
Available for sale debt securities	0	0
Available for sale debt securities	0	0
Debt Securities \| Level 2 \| Fair Value, Recurring
Assets:
Available for sale debt securities	0	0
Available for sale debt securities	0	0
Debt Securities \| Level 3 \| Fair Value, Recurring
Assets:
Available for sale debt securities	300,000	66,000
Available for sale debt securities	63,000	187,700
Forwards
Assets:
Available for sale debt securities	63,700	0
Available for sale debt securities	0	16,700
Liabilities:
Available for sale debt securities, liabilities current	0	0
Available for sale debt securities, liabilities noncurrent	(35,600)	0
Forwards \| Fair Value, Recurring
Assets:
Available for sale debt securities	63,700	0
Available for sale debt securities	0	16,700
Liabilities:
Forwards	(35,600)	0
Forwards \| Level 1 \| Fair Value, Recurring
Assets:
Available for sale debt securities	0	0
Available for sale debt securities	0	0
Liabilities:
Forwards	0	0
Forwards \| Level 2 \| Fair Value, Recurring
Assets:
Available for sale debt securities	0	0
Available for sale debt securities	0	0
Liabilities:
Forwards	0	0
Forwards \| Level 3 \| Fair Value, Recurring
Assets:
Available for sale debt securities	63,700	0
Available for sale debt securities	0	16,700
Liabilities:
Forwards	(35,600)	0
Money market funds \| Fair Value, Recurring
Assets:
Cash equivalents	307,797	598,253
Money market funds \| Level 1 \| Fair Value, Recurring
Assets:
Cash equivalents	307,797	598,253
Money market funds \| Level 2 \| Fair Value, Recurring
Assets:
Cash equivalents	0	0
Money market funds \| Level 3 \| Fair Value, Recurring
Assets:
Cash equivalents	0	0
Commercial paper \| Fair Value, Recurring
Assets:
Cash equivalents	181,681	13,997
Commercial paper \| Level 1 \| Fair Value, Recurring
Assets:
Cash equivalents	0	0
Commercial paper \| Level 2 \| Fair Value, Recurring
Assets:
Cash equivalents	181,681	13,997
Commercial paper \| Level 3 \| Fair Value, Recurring
Assets:
Cash equivalents	0	0
Certificates of deposit \| Fair Value, Recurring
Assets:
Cash equivalents	36,001	40,954
Certificates of deposit \| Level 1 \| Fair Value, Recurring
Assets:
Cash equivalents	0	0
Certificates of deposit \| Level 2 \| Fair Value, Recurring
Assets:
Cash equivalents	36,001	40,954
Certificates of deposit \| Level 3 \| Fair Value, Recurring
Assets:
Cash equivalents	$ 0	$ 0

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Fair value portion of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.

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Fair value, after the effects of master netting arrangements, of a financial asset or other contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.

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