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Fair Value Measurements and Financial Instruments - Summary of Change in Carrying Value of Level 3 Financial Instruments (Details) - USD ($) $ in Thousands |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 02, 2021 | Sep. 30, 2022 | Dec. 31, 2022 | Dec. 31, 2021
MorphoSys |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Maximum commitment to fund collaborative arrangement |  |  |  | $ 150,000
Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | MorphoSys |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Maximum commitment to fund collaborative arrangement | $ 150,000 | $ 150,000 | $ 150,000 |
Equity Securities | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 43,013 | 0
Purchases |  |  | 28,785 | 35,120
(Losses)/gains on equity securities |  |  | (22,634) | 7,893
Transfers out of Level 3 |  |  | (40,692) |
Balance at the end of the year |  |  | 8,472 | 43,013
Debt Securities | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 253,700 | 214,400
Purchases |  |  | 479,559 | 70,441
Gains/(losses) on initial recognition |  |  | 600 |
Unrealized gains on available for sale debt securities included in other comprehensive losses |  |  | 24,000 | 11,600
Losses/(gains) on available for sale debt securities included in earnings |  |  | (67,800) | 1,300
Settlement of forwards |  |  | 79,585 | 18,459
Redemption |  |  | (542,044) | (62,500)
Balance at the end of the year |  |  | 227,600 | 253,700
Forwards | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 16,700 | 18,600
Losses/(gains) on available for sale debt securities included in earnings |  |  | 62,885 | 16,559
Settlement of forwards |  |  | (79,585) | (18,459)
Balance at the end of the year |  |  | 0 | 16,700
Funding Commitments | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 0 |
Gains/(losses) on initial recognition |  |  | (9,400) |
Losses/(gains) on available for sale debt securities included in earnings |  |  | 6,900 |
Balance at the end of the year |  |  | (2,500) | 0
Derivative Instruments | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 0 |
Gains on derivative financial instruments |  |  | 96,610 |
Balance at the end of the year |  |  | 96,610 | 0
Royalty at Fair Value | Level 3 |  |  |  |
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] |  |  |  |
Balance at the beginning of the year |  |  | 0 |
Purchases |  |  | 21,215 |
Other non-operating expense |  |  | (6,715) |
Balance at the end of the year |  |  | $ 14,500 | $ 0

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