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Derivative Instruments - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Jul. 31, 2021
Feb. 29, 2020
Nov. 30, 2019
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Jun. 30, 2021
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Unrealized (Losses)/Gains         $ 65,891    
Derivative, notional amount             $ 600,000
Swap termination payments   $ 35,400   $ 0 16,093 $ 35,448  
Derivative collateral received   $ 45,300   0 34,660 $ 45,252  
Fair Value, Recurring              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Derivative instruments, current       86,150 0    
Derivative financial instruments       10,460 0    
Level 3 | Fair Value, Recurring              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Derivative instruments, current       86,150 0    
Derivative financial instruments       10,460 0    
Preferred Shares              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Unrealized (Losses)/Gains         $ 49,191    
Preferred Shares | Milestone Acceleration              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Unrealized (Losses)/Gains       $ 96,600      
Epizyme Common Stock Warrant              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Warrants to purchase additional shares (in shares)     2.5        
Equity Investment In Epizyme Inc.              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Equity securities     $ 100,000        
Upfront payment for equity investment     $ 100,000        
Equity Investment In Epizyme Inc. | Epizyme Common Stock Warrant              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Exercise price of warrant (in dollars per share)     $ 20        
Term of warrant (in years)     3 years        
Equity Investment In Epizyme Inc. | Put Option              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Put option, term (in months)     18 months        
Put option to sell additional common stock     $ 50,000        
Put option, selling price, maximum (in dollars per share)     $ 20        
Treasury rate lock contracts              
Derivative Instruments and Hedging Activities Disclosures [Line Items]              
Swap termination payments $ 16,100