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Insider Trading Arrangements
 3 Months Ended
Mar. 31, 2026
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
The following table describes the written plans for the sale of our Class A ordinary shares adopted or terminated by our executive officers and directors during the first quarter of 2026, each of which is intended to satisfy the affirmative defense conditions of Rule 10b5-1 (each, a “Trading Plan”):

Name and TitleActionAdoption/ Termination
Date
Scheduled Expiration Date of Trading Plan(1)
Maximum Shares Subject to Trading Plan
Terrance Coyne
Executive Vice President & Chief Financial Officer
AdoptionFebruary 24, 2026August 17, 2026
214,091 and EPA Shares(2)
Christopher Hite
Executive Vice President & Chairman,
Partnering & Investments
AdoptionMarch 20, 2026December 10, 2026630,000
Gregory Norden
Director
AdoptionFebruary 12, 2026December 31, 20267,614
Marshall Urist, M.D., Ph.D.
Executive Vice President, Research & Investments
Adoption
February 12, 2026(3)
May 26, 2026(3)
27,368 and EPA Shares(3)
(1)A Trading Plan may expire on an earlier date if all contemplated transactions are completed before such Trading Plan’s expiration date, upon termination by broker or the holder of the Trading Plan, or as otherwise provided in the Trading Plan.
(2)Maximum shares subject to trading plan consists of up to 214,091 Class A ordinary shares and 100% of the shares that may be issued upon settlement of the EPAs awarded for the first and second quarters of 2026.
(3)On February 12, 2026, Dr. Urist entered into a Trading Plan, scheduled to commence on May 14, 2026 and end on May 26, 2026, providing for the sale of up to 27,368 Class A ordinary shares. In addition, on March 25, 2026, Dr. Urist entered into a Trading Plan, scheduled to commence on June 24, 2026 and end on July 9, 2026, providing for the sale of up to 50% of the shares that may be issued upon settlement of EPAs awarded for the first quarter of 2026.
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Terrance Coyne [Member]  
Trading Arrangements, by Individual  
Name Terrance Coyne
Title Executive Vice President & Chief Financial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date February 24, 2026
Expiration Date August 17, 2026
Arrangement Duration 174 days
Aggregate Available 214,091
Christopher Hite [Member]  
Trading Arrangements, by Individual  
Name Christopher Hite
Title Executive Vice President & Chairman, Partnering & Investments
Rule 10b5-1 Arrangement Adopted true
Adoption Date March 20, 2026
Expiration Date December 10, 2026
Arrangement Duration 265 days
Aggregate Available 630,000
George Norden [Member]  
Trading Arrangements, by Individual  
Name Gregory Norden
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date February 12, 2026
Expiration Date December 31, 2026
Arrangement Duration 322 days
Aggregate Available 7,614
Marshall Urist, M.D., Ph.D. [Member]  
Trading Arrangements, by Individual  
Name Marshall Urist, M.D., Ph.D.
Title Executive Vice President, Research & Investments
Rule 10b5-1 Arrangement Adopted true
Adoption Date February 12, 2026
Expiration Date May 26, 2026
Arrangement Duration 103 days
Aggregate Available 27,368