<SEC-DOCUMENT>0001127602-22-005079.txt : 20220215
<SEC-HEADER>0001127602-22-005079.hdr.sgml : 20220215
<ACCEPTANCE-DATETIME>20220215173757
ACCESSION NUMBER:		0001127602-22-005079
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20220214
FILED AS OF DATE:		20220215
DATE AS OF CHANGE:		20220215

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lee Cassandra S.
		CENTRAL INDEX KEY:			0001851009

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-16189
		FILM NUMBER:		22640453

	MAIL ADDRESS:	
		STREET 1:		7615 ZIONSVILLE RD
		CITY:			INDIANAPOLIS
		STATE:			IN
		ZIP:			46268

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NISOURCE INC.
		CENTRAL INDEX KEY:			0001111711
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTRIC & OTHER SERVICES COMBINED [4931]
		IRS NUMBER:				352108964
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		801 EAST 86TH AVE
		CITY:			MERRILLVILLE
		STATE:			IN
		ZIP:			46410-6272
		BUSINESS PHONE:		2196475200

	MAIL ADDRESS:	
		STREET 1:		801 EAST 86TH AVE
		CITY:			MERRILLVILLE
		STATE:			IN
		ZIP:			46410-6272

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NISOURCE INC/DE
		DATE OF NAME CHANGE:	20001103

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NEW NISOURCE INC
		DATE OF NAME CHANGE:	20000412
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-02-14</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001111711</issuerCik>
        <issuerName>NISOURCE INC.</issuerName>
        <issuerTradingSymbol>NI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001851009</rptOwnerCik>
            <rptOwnerName>Lee Cassandra S.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>801 E. 86TH AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MERRILLVILLE</rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode>46410</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes></footnotes>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Kimberly V. Loies, Attorney-in-Fact</signatureName>
        <signatureDate>2022-02-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>doc1.txt
<DESCRIPTION>POWER OF ATTORNEY (PUBLIC): POA
<TEXT>
POWER OF ATTORNEY WITH RESPECT TO FORMS 3, 4 and
 5 AND FORM 144
      The undersigned hereby constitutes and appoints each of
Kimberly S. Cuccia and Kimberly V. Loies, signing singly, as the
undersigned's true and lawful attorneys-in-fact to:
(1)	execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer and/or director of
NiSource Inc., a Delaware corporation (the ?Corporation?),
Forms 3, 4, and 5 in accordance with Section?16(a) of
the Securities Exchange Act of 1934 and the rules thereunder
and Form 144 in accordance with Rule 144 under the
Securities Act of 1933;
(2)	do and perform any and all acts for and on
behalf of the undersigned which may be necessary or
desirable to complete and execute any such Form?3, 4, 5
or 144 and timely file such Form with the United States
Securities and Exchange Commission, either manually or
through the use of EDGAR, the Electronic Data Gathering,
Analysis, and Retrieval system, and with any stock
exchange or similar authority; and
(3)	take any other action of any type whatsoever in
connection with the foregoing which, in the opinion of
such attorney-in-fact, may be of benefit to, in the best
 interest of, or legally required by, the undersigned, it
being understood that the documents executed by such
 attorney-in-fact on behalf of the undersigned pursuant
 to this Power of Attorney shall be in such form and
shall contain such terms and conditions as such
attorney-in-fact may approve in such attorney-in-fact's
discretion.
      The undersigned hereby grants to each such
      attorney-in-fact full power and authority to do and perform
      any and every act and thing whatsoever requisite, necessary,
      or proper to be done in the exercise of any of the rights
      and powers herein granted, as fully to all intents and
      purposes as the undersigned might or could do if
      personally present, with full power of substitution or
      revocation, hereby ratifying and confirming all that
      such attorney-in-fact, or such attorney-in-fact's
      substitute or substitutes, shall lawfully do or cause to
      be done by virtue of this Power of Attorney and
      the rights and powers herein granted.  The undersigned
      acknowledges that the foregoing attorneys-in-fact, in
      serving in such capacity at the request of the undersigned,
      are not assuming, nor is the Corporation assuming,
      any of the undersigned's responsibilities to comply
      with Section?16 of the Securities Exchange Act
      of 1934 or Rule 144 under the Securities Act of 1933.
      This Power of Attorney revokes any previous powers of
	Attorney for the subject matter descriged above and shall
	remain in full force and effect until the undersigned is
	no longer required to file Forms?3, 4, 5 and 144 with
	respect to the undersigned?s holdings of and transactions
	in securities issued by the Corporation, unless earlier
	revoked by the undersigned in a signed writing delivered
	to the foregoing attorneys-in-fact.
      IN WITNESS WHEREOF, the undersigned has caused
      this Power of Attorney to be executed as of this
	14th day of February, 2022.
      /s/Cassandra Lee

</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
