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Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011
Cash flows from operating activities: |  |  |
Net income | $ 1,862,341 | $ 1,380,033 | $ 1,266,686
Adjustments to reconcile net income to net cash flows from operating activities: |  |  |
Depreciation and amortization of property, plant and equipment, and intangible assets | 531,740 | 365,648 | 358,933
Share-based compensation | 136,293 | 118,566 | 113,005
Deferred income taxes | (245,077) | (116,900) | 153,576
Other | (27,612) | 28,822 | 20,153
Changes in operating assets and liabilities, net: |  |  |
Accounts receivable | (126,753) | 3,571 | (73,374)
Inventory | (243,960) | (140,309) | (59,219)
Other assets | (160,188) | (27,347) | (43,241)
Accrued expenses and other current liabilities | 284,049 | 273,372 | 33,722
Other liabilities and taxes payable | 318,512 | 34,112 | (36,235)
Other | 15,733 | (39,671) | (6,265)
Net cash flows provided by operating activities | 2,345,078 | 1,879,897 | 1,727,741
Cash flows from investing activities: |  |  |
Proceeds from sales and maturities of marketable securities | 5,190,052 | 2,749,558 | 2,276,720
Purchases of marketable securities | (3,278,091) | (3,334,434) | (3,696,995)
Acquisition of TYSABRI rights | (3,262,719) | 0 | 0
Acquisitions of businesses and variable interest entities, net of cash acquired | (15,000) | (72,401) | (5,000)
Purchases of property, plant and equipment | (246,281) | (254,548) | (208,020)
Other | 7,371 | (38,517) | (16,999)
Net cash flows used in investing activities | (1,604,668) | (950,342) | (1,650,294)
Cash flows from financing activities: |  |  |
Purchase of treasury stock | (400,309) | (984,715) | (497,975)
Proceeds from issuance of stock for share-based compensation arrangements | 66,770 | 67,493 | 314,650
Excess tax benefit from share-based compensation | 73,467 | 54,738 | 50,586
Acquisition of noncontrolling interests | 0 | 0 | (148,264)
Repayments of borrowings | (452,340) | (2,428) | (11,459)
Other | (4,116) | (12,566) | (27,400)
Net cash flows used in financing activities | (716,528) | (877,478) | (319,862)
Net increase (decrease) in cash and cash equivalents | 23,882 | 52,077 | (242,415)
Effect of exchange rate changes on cash and cash equivalents | 7,959 | 4,102 | (2,641)
Cash and cash equivalents, beginning of the year | 570,721 | 514,542 | 759,598
Cash and cash equivalents, end of the year | $ 602,562 | $ 570,721 | $ 514,542

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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=6871852&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3179-108585 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=31814832&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=7656940&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a),(c) -URI http://asc.fasb.org/extlink&oid=18733093&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=31814832&loc=SL4591551-111686 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References No definition available. + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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