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Other Consolidated Financial Statement Detail (Details) (USD $)
 3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2013
Other Income (Expense), Net      
Interest income $ 2,700,000 $ 4,300,000  
Interest expense (7,600,000) (11,500,000)  
Impairment of investments 0 (300,000)  
Gain (loss) on sales of investments, net 3,000,000 4,400,000  
Foreign exchange gains (losses), net (3,300,000) (2,600,000)  
Other, net (400,000) (8,800,000)  
Total other income (expense), net (5,601,000) (14,457,000)  
Accrued Expenses and Other      
Employee compensation and benefits 198,100,000   343,400,000
Revenue-related rebates 330,500,000   264,900,000
Deferred revenue 205,400,000   172,700,000
Royalties and licensing fees 131,300,000   160,700,000
Clinical development expenses 58,100,000   55,200,000
Current portion of contingent consideration obligations 21,000,000   29,000,000
Construction in progress accrual 14,100,000   25,000,000
Collaboration expenses 4,800,000   18,700,000
Other 253,500,000   285,600,000
Total accrued expenses and other $ 1,216,843,000   $ 1,355,187,000