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Investments in Variable Interest Entities (Details) (USD $)
3 Months Ended 3 Months Ended 1 Months Ended 1 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2013
Mar. 31, 2014
Neurimmune
Mar. 31, 2013
Neurimmune
Feb. 28, 2014
Ataxion
Feb. 28, 2014
Commitments to invest
Ataxion
Feb. 28, 2014
Minority interest
Ataxion
Investment in Variable Interest Entities (Textual) [Abstract]                
Remaining potential development milestone payments and royalties on commercial sales under the terms of collaboration agreement       $ 345,000,000        
Research and development 528,884,000 284,340,000   11,000,000 5,000,000      
Payments to acquire interest in preferred stock of affiliate           1,600,000    
Term for right to purchase outstanding shares           30 days    
Additional investments committed to if certain milestones are met             6,200,000  
In-process research and development               3,500,000
Investment in biotechnology companies that are determined to be unconsolidated variable interest entities $ 10,500,000   $ 5,500,000