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Investments in Variable Interest Entities (Details) (USD $)
3 Months Ended 9 Months Ended 3 Months Ended 9 Months Ended 1 Months Ended 1 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Sep. 30, 2014
Sep. 30, 2013
Dec. 31, 2013
Sep. 30, 2014
Neurimmune
Jun. 30, 2014
Neurimmune
Sep. 30, 2013
Neurimmune
Sep. 30, 2014
Neurimmune
Sep. 30, 2013
Neurimmune
Feb. 28, 2014
Ataxion
Feb. 28, 2014
Commitments to invest
Ataxion
Feb. 28, 2014
Minority interest
Ataxion
Investment in Variable Interest Entities (Textual) [Abstract]                          
Remaining potential development milestone payments and royalties on commercial sales under the terms of collaboration agreement                 $ 335,000,000        
Research and development 417,174,000 410,017,000 1,393,331,000 1,021,820,000   7,400,000   6,100,000 29,100,000 16,800,000      
Milestone payments made during period             10,000,000            
Payments to acquire interest in preferred stock of affiliate                     1,600,000    
Term for right to purchase outstanding shares                     30 days    
Additional investments committed to if certain milestones are met                       6,200,000  
In-process research and development                         3,500,000
Investment in biotechnology companies that are determined to be unconsolidated variable interest entities $ 6,400,000   $ 6,400,000   $ 5,500,000