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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2015 | Jun. 30, 2014
Cash flows from operating activities: |  |
Net income | $ 1,744,999 | $ 1,202,860
Adjustments to reconcile net income to net cash flows from operating activities: |  |
Depreciation and amortization | 292,523 | 355,102
Share-based compensation | 93,677 | 83,856
Deferred income taxes | (90,647) | (146,506)
Other | (5,808) | (64,213)
Changes in operating assets and liabilities, net: |  |
Accounts receivable | (38,907) | (188,961)
Inventory | (81,294) | (72,689)
Accrued expenses and other current liabilities | (169,929) | (30,299)
Current taxes payable | 102,017 | 31,113
Other changes in operating assets and liabilities, net | (66,374) | (75,044)
Net cash flows provided by operating activities | 1,780,257 | 1,095,219
Cash flows from investing activities: |  |
Proceeds from sales and maturities of marketable securities | 975,517 | 1,317,525
Purchases of marketable securities | (2,045,046) | (1,787,606)
Acquisitions of business, net of cash acquired | (198,798) | 0
Purchases of property, plant and equipment | (227,688) | (118,308)
Contingent consideration related to Fumapharm AG acquisition | 250,000 | 25,000
Other | (10,119) | (10,745)
Net cash flows used in investing activities | (1,756,134) | (624,134)
Cash flows from financing activities: |  |
Purchase of treasury stock | (42,193) | (336,905)
Proceeds from issuance of stock for share-based compensation arrangements | 34,727 | 33,477
Excess tax benefit from stock options | 69,690 | 83,940
Other | 14,995 | 12,003
Net cash flows provided by (used in) financing activities | 77,219 | (207,485)
Net increase in cash and cash equivalents | 101,342 | 263,600
Effect of exchange rate changes on cash and cash equivalents | (24,188) | (2,965)
Cash and cash equivalents, beginning of the period | 1,204,924 | 602,562
Cash and cash equivalents, end of the period | $ 1,282,078 | $ 863,197

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration