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Share-Based Payments (Details) - USD ($) $ in Millions | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Share-based Compensation Expense included in consolidated statements of income |  |  |
Share-based compensation expense | $ (169.4) | $ (183.2) | $ (165.0)
Subtotal | 204.4 | 207.3 | 252.4
Capitalized share-based compensation costs | (14.6) | (11.0) | (10.0)
Share-based compensation expense included in total costs and expenses | 189.8 | 196.3 | 242.4
Income tax effect | (54.0) | (55.8) | (72.2)
Research and development |  |  |
Share-based Compensation Expense included in consolidated statements of income |  |  |
Share-based compensation expense | (84.5) | (88.6) | (102.1)
Selling, general and administrative |  |  |
Share-based Compensation Expense included in consolidated statements of income |  |  |
Share-based compensation expense | (121.7) | (127.3) | (150.3)
Restructuring charges |  |  |
Share-based Compensation Expense included in consolidated statements of income |  |  |
Share-based compensation expense | (1.8) | 8.6 | 0.0
Total share-based compensation expense, net of tax |  |  |
Share-based Compensation Expense included in consolidated statements of income |  |  |
Share-based compensation expense | $ (135.8) | $ (140.5) | $ (170.2)

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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