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Segment Information (Details) - USD ($) $ in Millions | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net | $ 2,502.9 | $ 2,539.6 | $ 2,466.0 | $ 2,309.4 | $ 2,425.9 | $ 2,391.7 | $ 2,198.6 | $ 2,172.3 | $ 9,817.9 | $ 9,188.5 | $ 8,203.4
U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 7,050.4 | 6,545.8 | 5,566.7
Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 2,767.5 | 2,642.7 | 2,636.7
TECFIDERA |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 3,968.1 | 3,638.4 | 2,909.2
TECFIDERA | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 3,169.4 | 2,908.2 | 2,426.6
TECFIDERA | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 798.7 | 730.2 | 482.6
AVONEX |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 2,313.5 | 2,630.2 | 3,013.1
AVONEX | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 1,675.3 | 1,790.2 | 1,956.7
AVONEX | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 638.2 | 840.0 | 1,056.4
PLEGRIDY |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 481.7 | 338.5 | 44.5
PLEGRIDY | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 305.0 | 227.1 | 27.8
PLEGRIDY | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 176.7 | 111.4 | 16.7
TYSABRI |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 1,963.8 | 1,886.1 | 1,959.5
TYSABRI | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 1,182.9 | 1,103.1 | 1,025.1
TYSABRI | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 780.9 | 783.0 | 934.4
FAMPYRA |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 84.9 | 89.7 | 80.2
FAMPYRA | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
FAMPYRA | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 84.9 | 89.7 | 80.2
ZINBRYTA |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 7.8 | 0.0 | 0.0
ZINBRYTA | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
ZINBRYTA | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 7.8 | 0.0 | 0.0
ELOCTATE |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 513.2 | 319.7 | 58.4
ELOCTATE | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 445.2 | 308.3 | 58.4
ELOCTATE | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 68.0 | 11.4 | 0.0
ALPROLIX |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 333.7 | 234.5 | 76.0
ALPROLIX | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 268.0 | 208.9 | 72.1
ALPROLIX | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 65.7 | 25.6 | 3.9
FUMADERM |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 45.9 | 51.4 | 62.5
FUMADERM | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
FUMADERM | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 45.9 | 51.4 | 62.5
SPINRAZA |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 4.6 | 0.0 | 0.0
SPINRAZA | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 4.6 | 0.0 | 0.0
SPINRAZA | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
BENEPALI |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 100.6 | 0.0 | 0.0
BENEPALI | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
BENEPALI | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 100.6 | 0.0 | 0.0
FLIXABI |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.1 | 0.0 | 0.0
FLIXABI | U.S |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | 0.0 | 0.0 | 0.0
FLIXABI | Rest of world |  |  |  |  |  |  |  |  |  |  |
Revenue by product |  |  |  |  |  |  |  |  |  |  |
Product, net |  |  |  |  |  |  |  |  | $ 0.1 | $ 0.0 | $ 0.0

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