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Intangible Assets and Goodwill (Tables) | 3 Months Ended
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Mar. 31, 2017
Goodwill and Intangible Assets Disclosure [Abstract] |
Intangible assets | Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
|  |  | As of March 31, 2017 |  | As of December 31, 2016
(In millions) | Estimated Life |  | Cost |  | Accumulated Amortization |  | Net |  | Cost |  | Accumulated Amortization |  | Net
Out-licensed patents | 13-23 years |  | $ | 543.3 |  |  | $ | (526.6 | ) |  | $ | 16.7 |  |  | $ | 543.3 |  |  | $ | (523.6 | ) |  | $ | 19.7 |
Developed technology | 15-23 years |  | 3,005.3 |  |  | (2,648.1 | ) |  | 357.2 |  |  | 3,005.3 |  |  | (2,634.3 | ) |  | 371.0 |
In-process research and development | Indefinite until commercialization |  | 653.7 |  |  | — |  |  | 653.7 |  |  | 648.0 |  |  | — |  |  | 648.0 |
Trademarks and tradenames | Indefinite |  | 64.0 |  |  | — |  |  | 64.0 |  |  | 64.0 |  |  | — |  |  | 64.0 |
Acquired and in-licensed rights and patents | 4-18 years |  | 3,887.1 |  |  | (874.8 | ) |  | 3,012.3 |  |  | 3,481.7 |  |  | (776.1 | ) |  | 2,705.6 |
Total intangible assets |  |  | $ | 8,153.4 |  |  | $ | (4,049.5 | ) |  | $ | 4,103.9 |  |  | $ | 7,742.3 |  |  | $ | (3,934.0 | ) |  | $ | 3,808.3 |
Estimated future amortization for acquired intangible assets | Based upon the above, the estimated future amortization of acquired intangible assets is expected to be as follows:
(In millions) | As of March 31, 2017
2017 (remaining nine months) | $ | 346.5 |
2018 | 425.5 |
2019 | 412.4 |
2020 | 378.5 |
2021 | 239.2 |
2022 | 216.7 |
Summary of roll forward of the changes in goodwill | The following table provides a roll forward of the changes in our goodwill balance:
(In millions) | As of March 31, 2017
Goodwill, beginning of period | $ | 3,669.3 |
Elimination of goodwill allocated to our hemophilia business | (314.1 | )
Increase to goodwill | 254.7 |
Other | 1.8 |
Goodwill, end of period | $ | 3,611.7 |

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- Definition Tabular disclosure of goodwill by reportable segment and in total which includes a rollforward schedule. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=35741047&loc=d3e13816-109267 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=35741047&loc=d3e13854-109267 + Details
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- Definition Tabular disclosure of the amount of amortization expense expected to be recorded in succeeding fiscal years for finite-lived intangible assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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