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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions | 6 Months Ended
--- | ---
Jun. 30, 2017 | Jun. 30, 2016
Cash flows from operating activities: |  |
Net income | $ 1,610.3 | $ 2,017.6
Adjustments to reconcile net income to net cash flows from operating activities: |  |
Depreciation, amortization and acquired in-process research and development | 814.6 | 325.1
Share-based compensation | 67.3 | 84.1
Deferred income taxes | (20.5) | (30.2)
Other | 73.5 | 28.9
Changes in operating assets and liabilities, net: |  |
Accounts receivable | (301.2) | (65.0)
Inventory | (85.3) | (128.3)
Accrued expenses and other current liabilities | (452.3) | (116.4)
Income tax assets and liabilities | (114.7) | (76.7)
Other changes in operating assets and liabilities, net | (187.3) | (25.1)
Net cash flows provided by operating activities | 1,404.4 | 2,014.0
Cash flows from investing activities: |  |
Proceeds from sales and maturities of marketable securities | 3,584.5 | 2,823.6
Purchases of marketable securities | (2,536.0) | (3,833.3)
Contingent consideration related to Fumapharm AG acquisition | 600.0 | 600.0
Acquired in-process research and development | (120.0) | 0.0
Purchases of property, plant and equipment | (407.7) | (263.7)
Acquisitions of intangible assets | (860.3) | 0.0
Other | (7.3) | (65.9)
Net cash flows used in investing activities | (946.8) | (1,939.3)
Cash flows from financing activities: |  |
Purchases of treasury stock | (1,365.4) | 0.0
Payments related to issuance of stock for share-based compensation arrangements, net | (17.8) | (21.9)
Net cash contribution to Bioverativ Inc. | 302.7 | 0.0
Other | 33.5 | 1.1
Net cash flows used in financing activities | (1,652.4) | (20.8)
Net (decrease) increase in cash and cash equivalents | (1,194.8) | 53.9
Effect of exchange rate changes on cash and cash equivalents | 37.8 | 0.1
Cash and cash equivalents, beginning of the period | 2,326.5 | 1,308.0
Cash and cash equivalents, end of the period | $ 1,169.5 | $ 1,362.0

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