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Intangible Assets and Goodwill (Tables) | 6 Months Ended
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Jun. 30, 2018
Goodwill and Intangible Assets Disclosure [Abstract] |
Intangible assets | Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
|  |  | As of June 30, 2018 |  | As of December 31, 2017
(In millions) | Estimated Life |  | Cost |  | Accumulated Amortization |  | Net |  | Cost |  | Accumulated Amortization |  | Net
Out-licensed patents | 13-23 years |  | $ | 543.3 |  |  | $ | (539.9 | ) |  | $ | 3.4 |  |  | $ | 543.3 |  |  | $ | (535.6 | ) |  | $ | 7.7 |
Developed technology | 15-23 years |  | 3,005.3 |  |  | (2,713.1 | ) |  | 292.2 |  |  | 3,005.3 |  |  | (2,689.0 | ) |  | 316.3 |
In-process research and development | Indefinite until commercialization |  | 670.5 |  |  | — |  |  | 670.5 |  |  | 680.6 |  |  | — |  |  | 680.6 |
Trademarks and tradenames | Indefinite |  | 64.0 |  |  | — |  |  | 64.0 |  |  | 64.0 |  |  | — |  |  | 64.0 |
Acquired and in-licensed rights and patents | 4-18 years |  | 3,974.2 |  |  | (1,343.0 | ) |  | 2,631.2 |  |  | 3,971.4 |  |  | (1,160.4 | ) |  | 2,811.0 |
Total intangible assets |  |  | $ | 8,257.3 |  |  | $ | (4,596.0 | ) |  | $ | 3,661.3 |  |  | $ | 8,264.6 |  |  | $ | (4,385.0 | ) |  | $ | 3,879.6 |
Estimated future amortization for acquired intangible assets | Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:
(In millions) | As of June 30, 2018
2018 (remaining six months) | $ | 215.8 |
2019 | 402.6 |
2020 | 380.9 |
2021 | 255.0 |
2022 | 242.3 |
2023 | 211.2 |
Summary of roll forward of the changes in goodwill | The following table provides a roll forward of the changes in our goodwill balance:
(In millions) | As of June 30, 2018
Goodwill, beginning of period | $ | 4,632.5 |
Increase to goodwill | 540.9 |
Other | (3.1 | )
Goodwill, end of period | $ | 5,170.3 |

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- Definition Tabular disclosure of goodwill by reportable segment and in total which includes a rollforward schedule. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=108376223&loc=d3e13816-109267 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 20 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=108376223&loc=d3e13854-109267 + Details
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