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Quarterly Financial Data (Unaudited) (Details Textual) - USD ($)
shares in Millions, $ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
May 31, 2018
Oct. 31, 2017
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Jun. 05, 2018
Schedule Of Development Milestone And Collaboration [Line Items]                            
Unrealized gain (loss) on strategic investments     $ (12.2) $ 141.2 $ 5.4 $ (6.4)                
Amortization of Intangible Assets                   $ 381.2 $ 455.3 $ 373.4    
GILTI     (544.6)       $ 0.0     (544.6) 0.0      
Loss (gain) on fair value remeasurement of contingent consideration                   12.3 (62.7) (14.8)    
Research and development                   2,597.2 2,253.6 1,973.3    
Acquired in-process research and development                   112.5 120.0 0.0    
Payments to Noncontrolling Interests                   36.4 134.1 0.0    
Net income (loss) attributable to noncontrolling interests, net of tax                   43.3 131.0 (7.1)    
Income tax benefit (expense)                   1,425.6 2,458.7 $ 1,237.3    
Bristol-Myers Squibb                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Research and development               $ 300.0   97.0        
iPerian                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Developmental Milestone Payment               60.0            
Alkermes                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Research and development             50.0     68.7 80.3      
Upfront And Milestone Payments Made To Collaborative Partner             28.0              
Ionis Pharmaceuticals                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Research and development expense on 2018 Ionis Agreement         486.2                  
Research and development         324.1               $ 10.0  
Premium on purchase of common stock                           $ 162.1
Investment in common stock, shares purchased                           11.5
Upfront And Milestone Payments Made To Collaborative Partner             25.0              
Neurimmune                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Payments to Noncontrolling Interests $ 50.0 $ 150.0                        
Additional reduction in royalty rate payable on commercial sales 5.00%                          
Net income (loss) attributable to noncontrolling interests, net of tax             150.0              
Reduction in royalty rate payable on commercial sales   15.00%                        
TECFIDERA                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Amortization of Intangible Assets     176.8           $ 328.2          
Karyopharm                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Acquired in-process research and development           $ 10.0                
Remedy Pharmaceutical                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Acquired in-process research and development               $ 120.0            
Pfizer                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Acquired in-process research and development         $ 75.0                  
AliveGen                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Acquired in-process research and development       27.5                    
In-process research and development                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Amortization of Intangible Assets       189.3                    
TGN                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Loss (gain) on fair value remeasurement of contingent consideration     80.6 89.6                    
TGN | In-process research and development                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
Amortization of Intangible Assets       $ 129.3                    
2017 Tax Act                            
Schedule Of Development Milestone And Collaboration [Line Items]                            
GILTI     135.8             135.8        
Income tax benefit (expense)                     1,173.6      
Transition toll tax liabilities     $ 697.0       $ 989.6     $ 697.0 $ 989.6